Two different synergy testing methods, the checkerboard and the E test methods, were used to compare the in vitro efficacies of various antimicrobial combinations against 16 Brucella melitensis strains isolated from blood cultures. The rate of agreement of the E test and checkerboard methods was found to be 55%. The most concordant results were found for the streptomycin-doxycycline combination in 12 (75%) tests, in which four strains showed synergistic activity by E test and antagonistic activity by the checkerboard method and in which one strain showed antagonistic activity by both methods. Even though each of these methods uses different conditions and endpoints, the results of both methods frequently agreed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC540140 | PMC |
| http://dx.doi.org/10.1128/JCM.43.1.140-143.2005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The in vitro Activity of Omadacycline Alone and in Combination Against Carbapenem-Resistant .
Infect Drug Resist
December 2024
Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Objective: This study aimed to evaluate the in vitro activity of omadacycline (OMC) and OMC-based combination therapy against carbapenem-resistant (CRKP).
Methods: The broth microdilution assay assessed the in vitro susceptibility of CRKP to OMC. The checkerboard assay was performed to evaluate the activity of OMC combined with polymyxin B (PB), amikacin (AN), or meropenem (MEM) against KPC-producing (class A) CRKP strains, and OMC combined with PB, aztreonam (ATM), MEM, or AN against class B and class A plus class B CRKP strains.
Structural characterization, cytotoxicity, antibiofilm activity, and synergistic potential with molecular docking analysis of ibuprofen-derived hydrazide against bacterial pathogens.
Microb Pathog
December 2024
State University of Ceará, Northeast Network of Biotechnology Program (RENORBIO), Campus Itaperi, Fortaleza, Brazil; Course of Chemistry, State University of Vale Acaraú, Sobral, Ceará, Brazil; Postgraduate in Natural Sciences, Sciences and Technology Center, State University of Ceará, Fortaleza, CE, Brazil. Electronic address:
The study investigates the synthesis, characterization, and antibacterial activity of an ibuprofen-derived hydrazide (HIDZ). It was synthesized and characterized using NMR spectroscopy, DFT Calculations, and ADMET studies. Furthermore, HIDZ cytotoxicity on L929 cells was evaluated using the MTT reduction assay.
View Article and Find Full Text PDFtest of the novel antibiotic lefamulin alone and in combination with doxycycline against .
Antimicrob Agents Chemother
December 2024
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
, a sexually transmitted bacterium, is a significant cause of urethritis in men and various reproductive tract infections in women, including cervicitis, pelvic inflammatory disease, endometritis, and potentially infertility. Treatment has become increasingly challenging due to the emergence of resistance to both first-line (azithromycin) and second-line (moxifloxacin) antibiotics. The need for new treatment options is critical.
View Article and Find Full Text PDFEfficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study.
Gut Pathog
December 2024
Microbiology and Immunology Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Background: Colistin resistance significantly constrains available treatment options and results in the emergence of pandrug-resistant (PDR) strains. Treating PDR infections is a major public health issue. A promising solution lies in using colistin-based combinations.
View Article and Find Full Text PDFTopology Optimization of Periodic Structures Subject to Self-Weight Loading Using a Heuristic Method.
Materials (Basel)
November 2024
Faculty of Mechanical Engineering, Cracow University of Technology, 31-155 Cracow, Poland.
This paper deals with the actual and challenging process of the optimal design of topologies of periodic structures taking into account the design-dependent loads. The topology formulation used in this paper minimizes the compliance value of the structure and is subject to a total volume constraint while maintaining a periodic pattern and self-weight load. This combination represents a promising and original contribution to the field of ongoing research, although it is not yet widely recognized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!