The regulation of filopodial dynamics by neurotrophins and other guidance cues plays an integral role in growth cone pathfinding. Filopodia are F-actin-based structures that explore the local environment, generate forces and play a role in growth cone translocation. Here, we review recent research showing that the actin-depolymerizing factor (ADF)/cofilin family of proteins mediates changes in the length and number of growth cone filopodia in response to brain-derived neurotrophic factor (BDNF). Although inhibition of myosin contractility also causes filopodial elongation, the elongation in response to BDNF does not occur through a myosin-dependent pathway. Active ADF/cofilin increases the rate of cycling between the monomer and polymer pools and is critical for the BDNF-induced changes. Thus, we discuss potential mechanisms by which ADF/cofilin may affect filopodial initiation and length change via its effects on F-actin dynamics in light of past research on actin and myosin function in growth cones.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1447-073x.2004.00087.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mapping of Global Research in Endodontics From 2004 to 2023: A Bibliometric Analysis.
Cureus
December 2024
Department of Population Health, King Abdullah International Medical Research Center, Riyadh, SAU.
Endodontics, a branch of dentistry, treats diseases and impairments in tissues within and surrounding the natural teeth. The aim of the study was to analyze the publication trends and key features of endodontic research published over the past 20 years across the globe. The quantitative bibliometric research approach was used to extract the data from the Web of Science database.
View Article and Find Full Text PDFConversion of Lignocellulosic Biomass Into Valuable Feed for Ruminants Using White Rot Fungi.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Animal Science, Wageningen University & Research, Wageningen, The Netherlands.
White rot fungi can degrade lignin and improve the nutritional value of highly lignified biomass for ruminants. We screened for excellent fungi-biomass combinations by investigating the improvement of digestibility of wheat straw, barley straw, oat straw, rapeseed straw, miscanthus, new reed, spent reed from thatched roofs, and cocoa shells after colonisation by Ceriporiopsis subvermispora (CS), Lentinula edodes (LE), and Pleurotus eryngii (PE) (indicated by increased in vitro gas production [IVGP]). First, growth was evaluated for three fungi on all types of biomass, over a period of 17 days in race tubes.
View Article and Find Full Text PDFEffects of maze appearance on maze solving.
Atten Percept Psychophys
January 2025
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, USA.
As mazes are typically complex, cluttered stimuli, solving them is likely limited by visual crowding. Thus, several aspects of the appearance of the maze - the thickness, spacing, and curvature of the paths, as well as the texture of both paths and walls - likely influence the performance. In the current study, we investigate the effects of perceptual aspects of maze design on maze-solving performance to understand the role of crowding and visual complexity.
View Article and Find Full Text PDFFlame Retardancy and Heat Shielding in Green Polypropylene Composites Using Biohybrid Fibers and Agro-Waste Fillers.
ACS Appl Bio Mater
January 2025
Department of Mechanical Engineering, Changwon National University, Changwon, Gyeongsangnam 51140, South Korea.
The current work presents the flame-retardant performance of hybrid polypropylene composites, reinforced with specific short woven flax fabrics (SWFs), short basalt fibers (BFs), and rice husk powder (RHP), using polypropylene grafted maleic anhydride (MAPP) as the coupling agent. Horizontal burning test (HBT), microcalorimeter test (MCT), and cone calorimeter test (CCT) were conducted on these composites. The formulations used were 25% SWF/PP, 25% SWF/20% BF/PP, and 25% SWF/20% BF/PP with 6% RHP and 25% SWF/20% BF/PP with varying RHP contents (6, 12, and 18%) in combination with 6% MAPP.
View Article and Find Full Text PDFPoint contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion.
J Cell Sci
January 2025
Sorbonne Université, INSERM, CNRS, Institut de la Vision, F-75012 Paris, France.
Signal transduction downstream of axon guidance molecules is essential to steer developing axons. Second messengers including cAMP are key molecules shared by a multitude of signaling pathways and are required for a wide range of cellular processes including axon pathfinding. Yet, how these signaling molecules achieve specificity for each of their downstream pathways remains elusive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!