Hepatitis G virus (HGV) was detected and described five years ago and up till now it presented unexplained problem for clinicians. Although reports on the pathogenicity of the virus are inconsistent, most researchers admit that the infection is very common. The aim of the study was an evaluation of HGV infection incidence rate among children with selected liver diseases. 150 children aged from 2 to 15 years with liver diseases (most with viral hepatitis B and C) were enrolled to the study. The existence of virus (HGV) genetic material in serum was estimated in all patients. On the basis of the analysis, the HGV infection was determined to be frequent in children with liver diseases (20.7%) and not dependent on sex and age. The contamination was more common in patients without viral hepatitis B and C than in children with chronic viral hepatitis B and C.
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Hum Genome Var
February 2024
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Congenital contractual arachnodactyly (CCA) is a genetic connective tissue disorder that is characterized by arachnodactyly, kyphoscoliosis, marfanoid habitus, and crumpled ears. We report a case of a boy with suspected Marfan syndrome. Genetic analysis revealed c.
View Article and Find Full Text PDFAdv Rheumatol
November 2023
UNIFESP, Rua Borges Lagoa, 913/ 51-53 - Vila Clementino, São Paulo, CEP: 04038-034, SP, Brazil.
Background: Some studies have suggested the HLA-B27 gene may protect against some infections, as well as it could play a benefit role on the viral clearance, including hepatitis C and HIV. However, there is lack of SARS-CoV-2 pandemic data in spondyloarthritis (SpA) patients.
Aim: To evaluate the impact of HLA-B27 gene positivity on the susceptibility and severity of COVID-19 and disease activity in axial SpA patients.
Hum Genome Var
December 2022
Toyama University of International Studies, 65-1, Higashi-Kuromaki, Toyama, Toyama, 930-1292, Japan.
TogoVar ( https://togovar.org ) is a database that integrates allele frequencies derived from Japanese populations and provides annotations for variant interpretation. First, a scheme to reanalyze individual-level genome sequence data deposited in the Japanese Genotype-phenotype Archive (JGA), a controlled-access database, was established to make allele frequencies publicly available.
View Article and Find Full Text PDFHum Genome Var
August 2022
Division of Genomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, Japan.
Dystonia (DYT) is a heterogeneous neurological disorder, and there are many types of DYT depending on the responsible genes. DYT11 is an autosomal dominant DYT caused by functional variants in the SGCE gene. We examined a Japanese patient with myoclonic dystonia.
View Article and Find Full Text PDFFront Immunol
June 2022
Medicine Service, Iowa City Veterans Administration Healthcare, Iowa City, IA, United States.
Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C). Sequence analyses found these two isolates to be the same virus, and subsequent studies found that the virus does not cause hepatitis despite sharing genome organization with hepatitis C virus.
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