Synthesis and catabolism of estradiol, the main estrogen from the period of maturation to menopause, is regulated for very complicated manner. Also many factors are involved in the process of absorption of orally given hormone. From this reason the body concentration of estradiol needs of permanently control. We studied of possibility to replace blood serum by saliva compared the concentrations of this hormone in the both body fluids. In this purpose estradiol was determined by the method of microparticle enzyme immunoassay (MEIA) in the blood and in the saliva obtained by the method of absorption with three different kits called "Salivette" in 25 women with pregnancy and in childbed. High correlation between concentrations of estradiol in saliva and blood serum was stated; the highest for polyester like absorption material.
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