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Harnessing the Engineered Probiotic-Nanosystem to Remodulate Tumor Extracellular Matrix and Regulate Tumor-Colonizing Bacteria for Improving Pancreatic Cancer Chemo-Immunotherapy.
Small
January 2025
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan, University, Wuhan, 430072, P. R. China.
Poor chemotherapy efficacy in pancreatic cancer is attributed to limited drug permeation caused by the dense extracellular matrix (ECM) and drug degradation induced by tumor-colonizing bacteria. Here, a tumor-targeting probiotic-nanosystem is elaborately designed to remodulate ECM and selectively regulate tumor-colonizing bacteria for improving chemo-immunotherapy against pancreatic cancer. Specifically, drug-loaded liposomes are conjugated with Clostridium Butyricum (CB) via matrix metalloproteinase-2 (MMP-2)-responsive peptide to construct a probiotic-nanosystem.
View Article and Find Full Text PDFAdvances in PIWI-piRNA function in female reproduction in mammals.
Acta Biochim Biophys Sin (Shanghai)
November 2024
Article Synopsis
- PIWI-interacting RNAs (piRNAs) help maintain genomic integrity and reproductive function by regulating transposable elements and protein-coding genes in germline cells.
- Recent findings in golden hamsters indicate that piRNAs play a critical role in female fertility, highlighting limitations in the mouse model for studying the PIWI-piRNA pathway.
- The review discusses advancements in piRNA research, its impact on female fertility, and future directions for understanding reproductive mechanisms in mammals.
Xyloglucan endotransglucosylase-hydrolase 1 is a negative regulator of drought tolerance in barley via modulating lignin biosynthesis and stomatal closure.
Plant Physiol Biochem
November 2024
College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China; Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou, 225009, China. Electronic address:
The projected increase in drought severity and duration worldwide poses a significant threat to crop growth and sustainable food production. Xyloglucan endotransglucosylase/hydrolases (XTHs) family is essential in cell wall modification through the construction and restructuring of xyloglucan cross-links, but their role in drought tolerance and stomatal regulation is still illusive. We cloned and functionally characterized HvXTH1 using genetic, physiological, biochemical, transcriptomic and metabolomic approaches in barley.
View Article and Find Full Text PDFSilence is golden, but my measures still see-why cheaper-but-noisier outcome measures in large simple trials can be more cost-effective than gold standards.
Trials
August 2024
Faculty of Epidemiology and Population Health, London, School of Hygiene and Tropical Medicine, London, UK.
Objective: To assess the cost-effectiveness of using cheaper-but-noisier outcome measures, such as a short questionnaire, for large simple clinical trials.
Background: To detect associations reliably, trials must avoid bias and random error. To reduce random error, we can increase the size of the trial and increase the accuracy of the outcome measurement process.
Silence is not always golden: A closer look at potential environmental and ecotoxicological impacts of large-scale dsRNA application.
Sci Total Environ
November 2024
Virginia Tech, School of Plant and Environmental Sciences, Alson H. Smith Jr. Agricultural Research, and Extension Center, Winchester, VA 22602, United States. Electronic address:
RNA interference (RNAi) technology has emerged as a pivotal strategy in sustainable pest management, offering a targeted approach that significantly mitigates the environmental and health risks associated with traditional insecticides. Originally implemented through genetically modified organisms (GMOs) to produce specific RNAi constructs, the technology has evolved in response to public and regulatory concerns over GMOs. This evolution has spurred the development of non-transgenic RNAi applications such as spray-induced gene silencing (SIGS), which employs double-stranded RNA (dsRNA) to silence pest genes directly without altering the plant's genetic makeup.
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