Realizing the promise and managing the success of organ transplantation requires the creation of unique institutions. An Organ Procurement and Transplant Network (OPTN) must be capable of increasing the supply of cadaver donor organs, of allocating those organs properly to recipients with due consideration for equity and utility, and of using scientific data to improve the system for the good of society. The OPTN should answer to the public and should expect public support. Both in the United States and in Korea major changes in deceased donor organ procurement and allocation are in progress. In the United States change takes the form of a renewed emphasis on achieving equity in kidney allocation without significantly sacrificing transplant graft or patient survival and the first ever use of purely objective, statistically evaluated criteria for liver allocation. In Korea where the OPTN is only four years old, change takes the form of a new brain death law and the creation of that country's first organ procurement organizations. In both countries, success in meeting the transplant needs of their populations will ultimately depend on the support of society and the cooperation of the entire medical community.
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http://dx.doi.org/10.3349/ymj.2004.45.6.1035 | DOI Listing |
BMJ Open
January 2025
Nursing, Brock University, St. Catharines, Ontario, Canada.
Objectives: This study aimed to explore the perceptions of donation coordinators in Canada and understand how the COVID-19 pandemic impacted their work activities.
Design: A sequential mixed-method design incorporating a cross-sectional survey investigating demographic data, substance use and abuse and perceived stress related to the pandemic and semistructured qualitative interviews to further investigate those.
Setting: Organ donation organisations across Canada.
Transplant Proc
January 2025
Department of Surgery, Tulane University, New Orleans, Louisiana. Electronic address:
Background: Organ procurement from brain-dead pregnant women is rare and typically occurs postfetal delivery. In this case report, we describe organ procurement from a brain-dead woman in her third trimester of pregnancy with a nonviable fetus remaining in utero.
Case Summary: We report a 33-year-old woman at 38 weeks gestation who suffered anoxic brain injury following cardiac arrest due to suspected opioid overdose.
PLoS One
January 2025
Worldwide Health Economics and Outcomes Research, Bristol Myers Squibb, Princeton, NJ, United States of America.
Background: Belatacept is approved for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients and is associated with a risk of post-transplant lymphoproliferative disorder (PTLD).
Methods: Data from the Organ Procurement and Transplantation Network were used to examine patterns of belatacept use, describe patient characteristics, and estimate risk of PTLD in EBV-seropositive, kidney-only transplant recipients receiving belatacept- or calcineurin inhibitor (CNI)-based immunosuppression as part of US Food and Drug Administration-mandated safety monitoring.
Results: During the study period (June 15, 2011-June 14, 2016), 94.
Clin Transplant
January 2025
Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Background: The use of donor kidneys with acute kidney injury (AKI) aims to expand the organ pool, but uncertainty remains regarding their outcomes across different Kidney Donor Profile Index (KDPI) groups and preservation methods.
Methods: We retrospectively analyzed 108 160 deceased donor kidney transplants from the OPTN database, focusing on adult recipients of kidneys from donors with or without AKI between December 2014 and December 2022. Propensity matching was used for each KDPI group (1-20, 21-59, 60-84, and 85-100), comparing donors with AKIN stages 0-1 to AKIN stages 2-3.
Ann Thorac Surg Short Rep
September 2024
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Background: Organ procurement organizations coordinate organ donation through 2 distinct models of care: the conventional model, in which donors are managed at hospitals where brain death occurs, and the specialized donor care facility (SDCF) model, where brain dead donors are transferred to a freestanding facility. The aim of this study is to compare operating room efficiency for procurements between the SDCF and conventional models of care.
Methods: We performed a prospective analysis of operating room efficiency between thoracic donor procurement operations performed at a SDCF and other organ procurement organizations using the conventional model of care.
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