Study Design: A case of destructive spondyloarthropathy was reported.
Objectives: To describe the rapid destruction of intervertebral disc and vertebral body as a consequence of destructive spondyloarthropathy in a patients with end-stage renal disease receiving hemodialysis.
Summary Of Background Data: An important facet of this case is that the serial radiographs provide key information about the rapid nature of dialysis associated destructive spondyloarthropathy, a condition which has been increasingly recognized over the last 2 decades.
Methods: The clinical and radiologic features of a 55-year-old dialysis patient with destructive spondyloarthropathy are herein detailed. Her serial radiographs and magnetic resonance images have implications both for our understanding of the underlying destructive process and its clinical evaluation.
Results: Serial lateral lumbar spines illustrated that the destructive process started at the leading edge of the endplate of vertebral body, closely followed by adjacent intervertebral disc destruction that appeared in parallel with vertebral body bone resorption.
Conclusions: A case of dialysis-associated destructive spondyloarthropathy was reported, with key information about its rapid nature being provided by serial radiographs.
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Egypt J Immunol
January 2025
Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Psoriasis (PsO) is a chronic immune-mediated disease of the skin. Psoriatic arthritis (PsA) is a prevalent chronic inflammatory disease that is associated with joint destruction and disability. The presence of PsO is the single greatest risk factor for the development of PsA.
View Article and Find Full Text PDFArch Osteoporos
December 2024
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Erciyes University, 38030, Kayseri, Turkey.
Paget's disease is a condition marked by abnormal bone remodeling, involving both excessive bone formation and destruction, predominantly in the elderly. Pagetic vertebral ankylosis is a rare manifestation, often associated with Paget's disease, ankylosing spondylitis, or diffuse idiopathic skeletal hyperostosis. This form of acquired vertebral ankylosis is uncommon and occurs in cases with bone-bridging syndesmophytes or osteophytes.
View Article and Find Full Text PDFEur Spine J
November 2024
Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
Purpose: Destructive spondyloarthropathy (DSA) is a serious complication of long-term haemodialysis; it commonly occurs in the cervical spine and has been investigated in cervical lesions. Although DSA of the lumbar spine has been reported, only few studies have investigated this, and the characteristics of patients with lumbar DSA are unclear. The present study aimed to elucidate the prevalence of DSA and its clinical characteristics in patients with DSA in the lumbar spine using computed tomography (CT) images of the patients who underwent lumbar spine surgery.
View Article and Find Full Text PDFCytokine Growth Factor Rev
August 2024
Department of Internal Medicine 3, Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie DZI, Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address:
Psoriatic arthritis (PsA) is part of the psoriatic disease spectrum and is characterized by a chronic inflammatory process that affects entheses, tendons and joints. Cytokines produced by immune and non-immune cells play a central role in the pathogenesis of PsA by orchestrating key aspects of the inflammatory response. Pro-inflammatory cytokines such as TNF, IL-23 and IL-17 have been shown to regulate the initiation and progression of PsA, ultimately leading to the destruction of the architecture of the local tissues such as soft tissue, cartilage and bone.
View Article and Find Full Text PDFBMC Musculoskelet Disord
July 2024
Department of Orthopedic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Background: Andersen's lesion (AL) is a rare complication of ankylosing spondylitis (AS), characterized by nonneoplastic bone destruction, typically manifested as bone destruction and sclerosis in the vertebral body and/or intervertebral disc area. At present, there is no consensus on the pathology and etiology of AL. Repeated trauma, inflammation in essence and part of the natural history of Ankylosing spondylitis itself are the most widely recognized theories of the etiology of AL.
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