[Advances in studies of biological clock gene].

The circadian clock genes, which generate and control the running of the circadian rhythms, exist in organisms ranging from prokaryotes to mammals. The oscillator genes and its coding proteins compose the feedback loops of circadian system. The kind, number and regulating route of clock genes are characterized by living things at different evolution levels. The molecular mechanism of the run of circadian clock genes in cyanobacteria, neurospore, fruit fly, mouse and human being is introduced in this article.