AI Article Synopsis
- The study aimed to explore the surface complexity of the prefrontal cortex and hemispheric asymmetry in first-episode schizophrenia patients.
- MRI scans were conducted on three groups: first-episode schizophrenia patients, first-episode affective psychosis patients, and age-matched healthy controls.
- Results indicated that while there was no significant difference in cortical complexity, schizophrenia patients showed reduced left-right asymmetry compared to healthy controls, suggesting a neurodevelopmental link to the disorder.
Article Abstract
Objective: The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia.
Method: An estimate of the surface complexity of the prefrontal cortex was derived from the number of voxels along the boundary between gray matter and CSF. Magnetic resonance imaging scans were acquired from patients with a first episode of schizophrenia (N=17), patients with a first episode of affective psychosis (N=17), and normal comparison subjects (N=17), age-matched within a narrow age range (18-29 years). This study group was the focus of a previous study that showed lower prefrontal cortical volume in patients with schizophrenia.
Results: Prefrontal cortical complexity was not significantly different among the groups. However, the schizophrenia patients differed significantly from the normal comparison subjects in asymmetry, with the schizophrenia patients showing less left-greater-than-right asymmetry in cortical complexity than the comparison subjects.
Conclusions: An abnormal pattern of asymmetry in the prefrontal cortex of first-episode patients with schizophrenia provides evidence for a neurodevelopmental mechanism in the etiology of schizophrenia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768063 | PMC |
| http://dx.doi.org/10.1176/appi.ajp.162.1.65 | DOI Listing |
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