Photomodulation is a process that manipulates or regulates cell activity using light sources without thermal effect. Previous studies of LED photomodulation have shown skin textural improvement accompanied by increased collagen deposition with reduced MMP-1 (collagenase) activity in the papillary dermis. The purpose of this study was to investigate a separate cohort of patients (N =93) with a wide range of Fitzpatrick skin types treated by LED photomodulation using the Gentlewaves full panel 590 nm high energy LED array with a specific sequence or code of pulsing in the millisecond domain. Results showed improvement of signs of photoaging in 90%. The majority of patients demonstrated improvement in peri-ocular wrinkles, reduction in Fitzpatrick photoaging classification, global skin texture and background erythema, and pigmentation. No side effects were noted. LED photomodulation is a safe and effective non-painful non-ablative modality for improvement of photoaging.
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Physiol Plant
November 2024
Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
Innovations in light technologies (i.e. Light Emitting Diodes; LED) and cover films with specific optical features (e.
View Article and Find Full Text PDFProtein Sci
November 2023
Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Acid-sensing ion channels (ASICs) are important players in detecting extracellular acidification throughout the brain and body. ASICs have large extracellular domains containing two regions replete with acidic residues: the acidic pocket, and the palm domain. In the resting state, the acidic pocket is in an expanded conformation but collapses in low pH conditions as the acidic side chains are neutralized.
View Article and Find Full Text PDFGels
December 2022
Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.
The endovascular treatment of cerebral aneurysms has become widespread but may still be limited by recurrence rates or complications. The discovery of novel embolic strategies may help mitigate these concerns. We formulated a Photosensitive Hydrogel Polymer (PHP) embolic agent which is low-viscosity, shear-thinning, and radio-opaque.
View Article and Find Full Text PDFJ Photochem Photobiol B
January 2023
Anhembi Morumbi University (UAM), Institute of Biomedical Engineering, Estrada Dr. Altino Bondensan 500, Distrito de Eugênio de Melo, CEP: 12.247-016 São José dos Campos, SP, Brazil; Center of Innovation, Technology and Education - (CITE), Estrada Dr. Altino Bondensan 500, Distrito de Eugênio de Melo, CEP: 12.247-016 São José dos Campos, SP, Brazil. Electronic address:
Background: COVID-19 disease is caused by SARS-CoV-2 which can trigger acute respiratory syndrome, which presents with dense alveolar and interstitial infiltrates and pulmonary edema, causing severe hypoxemia and significant alteration to pulmonary mechanics with reduced pulmonary compliance. The photobiomodulation technique alters cellular and molecular metabolism, showing promising results regarding the reduction of acute pulmonary inflammation.
Objective: To compare the photomodulation technique using near-infrared LED to conventional respiratory physiotherapy treatment in patients with COVID-19 in reversing acute conditions, reducing hospitalization time, and decreasing the need for oxygen therapy.
ACS Appl Mater Interfaces
August 2022
The Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246 Nadia, India.
Photo-responsive supramolecular systems offer intriguing functional aspects which have led to their applications in diverse fields such as optoelectronics and biomedicine. However, the modulation of the luminescence output in a spatiotemporal fashion by photo-controlled transformation still remains a challenging task. Herein, we report the controlled regulation of the emission color of supramolecular assemblies of amphiphilic cyanostilbenes (CSs) in water through in situ photomodulation employing UV and sunlight.
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