AI Article Synopsis
- Human malignant tumors show abnormal cell growth due to changes in cell cycle regulation.
- These regulatory pathways involve oncogenes and tumor suppressor genes, which can serve as markers for ovarian cancer progression and treatment response.
- The review categorizes cell cycle-regulatory genes into four subgroups based on their main roles in specific phases of the cell cycle.
Article Abstract
Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes that display a range of abnormalities with potential usefulness as markers of evolution or treatment response in ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle.
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| http://dx.doi.org/10.1158/1078-0432.CCR-04-0886 | DOI Listing |
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