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Thrombosis in Children: A Retrospective Study from a Single-center Database.
In Vivo
December 2024
Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Background/aim: The incidence and characteristics of pediatric thrombotic events have become increasingly recognized, due to the enhanced utilization of advanced diagnostic techniques. Pediatric thrombosis remains less frequent than in adults, often manifesting in those with underlying congenital or acquired risk factors. This study aimed to establish epidemiological data on pediatric thrombotic events in Bihor County, Romania, highlighting the challenges of diagnosis in smaller medical centers and proposing a relevant diagnostic and treatment algorithm.
View Article and Find Full Text PDFResults of a multinational survey on the diagnostic and management practices of catheter-related arterial thrombosis in children and neonates: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.
J Thromb Haemost
December 2024
Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Pediatric Hematology-Oncology Unit, Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, and Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland. Electronic address:
Background: Arterial thrombosis is increasingly recognized in children and is most commonly related to the presence of an arterial catheter. Diagnosis and treatment of arterial thrombosis in children varies widely and consists of commonly available anticoagulants and antiplatelet drugs. No evidence-based guidelines exist for management strategies of catheter related arterial thrombosis (CAT).
View Article and Find Full Text PDFCharacteristics of the pregnancy and labour course in women who underwent COVID-19 during pregnancy.
J Perinat Med
December 2024
Department of Obstetrics and Gynaecology, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.
Objectives: This study aims to analyze the impact of COVID-19 on pregnancy and labor, focusing on its effects on maternal and child health. The research explores the relationships between coronavirus infection and clinical and laboratory parameters, as well as the risks of pregnancy complications and adverse birth outcomes.
Methods: The study involved 60 pregnant women diagnosed with COVID-19.
Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice.
Arterioscler Thromb Vasc Biol
December 2024
Department of Biochemistry, Jichi Medical University School of Medicine, Tochigi, Japan (T.T., N.B., Y.K., M.H., T.H., T.O.).
Article Synopsis
- PC is a crucial plasma anticoagulant, and mutations in both alleles can lead to a serious condition called neonatal purpura fulminans.
- The study developed a genome editing approach using engineered activated protein C (APC) to treat congenital PC deficiency by expressing it in mouse liver through adeno-associated virus vectors and CRISPR/Cas9.
- Results showed that the engineered APC prolonged coagulation time, inhibited harmful thrombus formation, and improved the survival of PC-deficient mice, indicating its potential as a cure for this severe condition.
Clinical implications of genetic testing for congenital protein C deficiency in pregnancy.
J Obstet Gynaecol Res
December 2024
Nara Medical University, Department of obstetrics and gynecology, Kashihara, Nara, Japan.
Congenital protein C (PC) deficiency is a mostly autosomal dominant hereditary thrombophilia associated with early onset arterial and venous thrombotic diseases. In newborns, PC deficiency results in severe complications such as cerebral hemorrhage, cerebral infarction, and purpura fulminans, leading to death in some cases. We report two cases of deep vein thrombosis diagnosed during pregnancy that prompted genetic testing confirming definitive congenital PC deficiency.
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