Lyme borreliosis is due to infection with the tick-borne spirochete Borrelia burgdorferi, and is associated with persistent infection unless treated with antibiotics. The persistent nature of infection by B. burgdorferi can lead to development of chronic disease, as found in patients infected before recognition of the effectiveness of antibiotic therapy. Much speculation has surrounded the possibility that autoimmune mechanisms are involved in chronic symptoms. In most cases, involvement of autoimmunity in Lyme disease has not received experimental support. The exception is in a small group of patients with chronic arthritis whose abnormal joint symptoms persist after apparent elimination of the bacteria. In this review, the evidence supporting autoimmune mechanisms in Lyme disease will be discussed.
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases.
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Vibrant Sciences LLC., San Carlos, CA, USA.
Tick-borne infections are the most common vector-borne diseases in the USA. Ticks harbor and transmit several infections with Lyme disease being the most common tickborne infection in the US and Europe. Lack of awareness about tick populations, specific diagnostic tests, and overlapping signs and symptoms of tick-borne infections can often lead to misdiagnosis affecting treatment and the prevalence data reported especially for non-Lyme tick-borne infections.
View Article and Find Full Text PDFUnlabelled: The spirochete causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis. In such patients, persistence of antigenic peptidoglycan (PG ) fragments within joint tissues may contribute to the immunopatho-genesis, even after appropriate antibiotic treatment.
View Article and Find Full Text PDFUnlabelled: How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that ticks infected with either (causative agent of anaplasmosis) or (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR).
View Article and Find Full Text PDFMolecular prevalence of , and in dogs and associated ticks in Egypt: Emerging One Health challenging zoonoses.
Vet World
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Department of Microbiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background And Aim: Tick-borne pathogens pose a significant problem in canines, other animals, and humans worldwide. This study aimed to estimate the prevalence of , and in dogs and associated ticks in Egypt.
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Pathogen presence, prevalence, and diversity in and mammal hosts at their expanding northern range limits.
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Department of Biology, McGill University, Montreal, QC, Canada.
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