D-glucosaminic acid (2-amino-2-deoxy-D-gluconic acid), a component of bacterial lipopolysaccharides and a chiral synthon, is easily prepared on a multigram scale by air oxidation of D-glucosamine (2-amino-2-deoxy-D-glucose) catalysed by glucose oxidase.
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http://dx.doi.org/10.1016/j.carres.2004.10.013 | DOI Listing |
J Am Chem Soc
January 2024
Center for Evolutionary Chemical Biology, Department of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.
It is well established that the dynamic hydration shell plays a vital role in macromolecular functions such as protein-ligand, protein-protein, protein-DNA, and protein-lipid interactions. Here we investigate how the water modality affects conformational changes, solubility, and motion of fibrillar proteins. The hypothesis is that the introduction of a poly hydroxyl amino acid would increase solvation of the fibril forming peptides, preventing their misfolding and aggregation.
View Article and Find Full Text PDFSci Rep
November 2023
DRDO-Defence Institute of High-Altitude Research (DIHAR), Ministry of Defence, Leh, 194101, UT Ladakh, India.
Recently, there has been considerable interest in the functions of gut microbiota in broiler chickens in relation to their use as feed additives. However, the gut-microbiota of chickens reared at different altitudes are not well documented for their potential role in adapting to prevailing conditions and functional changes. In this context, the present study investigates the functional diversity of gut-microbes in high-altitude (HACh) and low-altitude adapted chickens (LACh), assessing their substrate utilization profile through Biolog Ecoplates technology.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
April 2023
State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China.
Currently, the genus comprises 76 recognized species. Members of are mostly isolated from environmental, animal, and plant sources. This report describes and proposes a novel species of isolated from clinical specimens of the human ocular surface.
View Article and Find Full Text PDFChem Asian J
September 2022
China-UK Low Carbon College, Shanghai Jiao Tong University, 3 Yinlian Rd, Shanghai, P. R. China.
In this study, glucosaminic acid (GlcNA) was produced with the highest yield of ∼85% from chitin biomass-derived glucosamine (GlcN) at 35 °C under atmospheric air in water, by using zinc oxide-supported gold nanoparticles (Au/ZnO). The Au/ZnO catalyst prepared by the deposition-precipitation (DP) method displayed remarkably superior catalytic performance to that prepared by the deposition-reduction (DR) method, which led to >2-fold enhancement in product yield. A lower apparent activation energy (E ) was observed over the Au/ZnO (DP) for GlcNA formation compared with the Au/ZnO (DR) catalyst.
View Article and Find Full Text PDFBiochemistry
May 2021
Department of Genetics, University of Georgia, Athens, Georgia 30602, United States.
d-Glucosaminate-6-phosphate ammonia-lyase (DGL) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that produces 2-keto-3-deoxygluconate 6-phosphate (KDG-6-P) in the metabolism of d-glucosaminic acid by serovar typhimurium. We have determined the crystal structure of DGL by SAD phasing with selenomethionine to a resolution of 2.58 Å.
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