Karnatakafurans A (1) and B (2), two novel dibenzofurans, have been isolated from the Specie Novum Aspergillus karnatakaensis Frisvad. The compounds were the major secondary metabolites and were isolated through UV-guided fractionation of the organic extract. The structures were elucidated by spectroscopic methods including MS and NMR. The compounds were tested for antimicrobial and antimalarial activity and proved to be moderately active against Plasmodium falciparum.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/np049843k | DOI Listing |
Molecules
November 2024
Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230012, China.
Nine new compounds (-), including four dihydrochalcone glycosides, two dibenzofuran glycosides, and two biphenyl glycosides, were isolated from the leaves of the medicinal plant collected in Shennongjia Forestry District (Hubei, China). Their structures were elucidated by comprehensive spectroscopic techniques, including HRESIMS and NMR spectra. All compounds were tested by preliminary biological evaluation for their α-glucosidase inhibitory and NO production activities.
View Article and Find Full Text PDFPhytopathology
October 2024
TU Braunschweig University, Institute of Pharmaceutical Biology, Mendelssohnstr. 1, Braunschweig, Braunschweig, NIEDERSACHSEN, Germany, 38106;
Apple replant disease (ARD) is a serious soilborne disease in apple nurseries and orchards worldwide. ARD is the result of an unbalanced soil microbiome in which multiple soil-borne plant pathogenic fungi, oomycetes and nematodes form a disease complex. Biphenyl and dibenzofuran phytoalexins are found in greater quantities in the roots of apple plants grown in ARD soil compared to disinfected ARD soil.
View Article and Find Full Text PDFPhytochemistry
January 2025
School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, PR China; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China. Electronic address:
Parrotia subaequalis, an endangered Tertiary relict tree native to China and a member of the Hamamelidaceae family, is one of several host plant species in this family that exhibit unique ecological habits, such as gall formation. Tree galls are the results of complex interactions between gall-inducing insects and their host plant organs. The formation of galls may serve to protect other regions of the plant from potential damage, often through the production of phytoalexins.
View Article and Find Full Text PDFFitoterapia
December 2024
Laboratory of Cell and Molecular Biology, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata 700 019, West Bengal, India. Electronic address:
The non-specificity of contemporary cancer therapeutics has enticed us to develop safer, anticancer alternatives from natural resources. Lichens are unique natural entities which have long been neglected for explorations in cancer therapy, despite their vast potential. Our present study aims to investigate the anti-cancer potential of a wild lichen Parmelinella wallichiana.
View Article and Find Full Text PDFBioorg Chem
March 2024
Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali University, Dali 671000, China; Institute of Materia Medica & College of Pharmacy, Dali University, Dali 671000, China. Electronic address:
Dibenzofurans are a small class of natural products with versatile biological activities that used to be thought to come mainly from lichens and ascomycetes. In fact, they are also distributed widely in higher plants, especially in the families Rosaceae and Myrtaceae. Dibenzofurans and derivatives from lichens and ascomycetes have been well reviewed, but dibenzofurans from all biological sources in nature have not been reviewed.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!