Submicroscopic and ultracytochemical changes in lymphocytes containing Gall body complex in the cytoplasm, have been studied in the blood of patients with type 1 and 2 diabetes mellitus, Hodgkin disease, and clean-up workers of the Chernobyl accident. It has been shown that each pathological state was characterized by specific changes in the ultrastructure of Gall body complex, that pointed out its important role in the function of this type of lymphocytes and may be used as an additional cytological criterion in the estimation of T-immunity status.
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Front Immunol
October 2024
Division of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, United States.
J Vet Diagn Invest
November 2024
Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR, China.
Literature covering diseases of the giant panda () is either in Chinese or focuses on infectious agents. Here we describe the clinical signs, gross and microscopic findings, and immunohistochemistry results of a B-cell lymphoma in multiple organs of a 35-y-old captive male giant panda. The animal was euthanized because of prolonged anorexia and vomiting.
View Article and Find Full Text PDFKorean J Clin Oncol
May 2024
Department of Pathology, Safdarjung Hospital, Vardhman Mahavir Medical College, New Delhi, India.
Purpose: Gallbladder carcinoma (GBC) poses significant challenges in oncology due to its aggressive nature and limited treatment options. The lack of effective biomarkers for early detection and prognosis exacerbates the prognosis for GBC patients. Tumor budding (TB) and tumor infiltrating lymphocytes (TILs) have emerged as potential prognostic indicators in various cancers, reflecting tumor-host immune interactions and tumor aggressiveness.
View Article and Find Full Text PDFJ Toxicol Pathol
July 2024
Labcorp Early Development, 3301 Kinsman Blvd, Madison, WI, USA.
The historical control database of a multinational laboratory services provider was queried for all histopathologic findings in New Zealand White rabbits which were used as control animals during a ten-year period (2011-2020). The query included all evaluated tissues, with or without microscopic findings, in studies conducted for safety testing for regulatory approval by the U.S.
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