AI Article Synopsis

Article Abstract

Submicroscopic and ultracytochemical changes in lymphocytes containing Gall body complex in the cytoplasm, have been studied in the blood of patients with type 1 and 2 diabetes mellitus, Hodgkin disease, and clean-up workers of the Chernobyl accident. It has been shown that each pathological state was characterized by specific changes in the ultrastructure of Gall body complex, that pointed out its important role in the function of this type of lymphocytes and may be used as an additional cytological criterion in the estimation of T-immunity status.

Download full-text PDF

Source

Publication Analysis

Top Keywords

lymphocytes gall
8
blood patients
8
diabetes mellitus
8
mellitus hodgkin
8
hodgkin disease
8
disease clean-up
8
clean-up workers
8
workers chernobyl
8
gall body
8
body complex
8

Similar Publications

Article Synopsis
  • There is limited research on how different anesthetic techniques impact antitumor immunity in gall bladder cancer patients, leading to a study comparing propofol-based total intravenous anesthesia with sevoflurane-based general anesthesia.
  • A pilot trial involving 64 patients revealed that propofol raised serum levels of tumor growth factor-β (TGF-β), while sevoflurane increased levels of interleukin-17A, indicating a shift toward TH17 cell activity.
  • The study suggests that the choice of anesthesia may influence immune responses in gall bladder cancer patients, but further extensive research is needed to validate these findings.
View Article and Find Full Text PDF
Article Synopsis
  • Pathogenic variants in a specific transcription factor are linked to syndromes like EEC and AEC, and this case report presents an infant with severe T cell lymphopenia, detected during newborn screening.
  • Flow cytometry revealed low levels of CD4+ and almost no CD8+ T cells, while the B and NK cell levels were normal; further genetic analysis identified a particular variant in the transcription factor.
  • Using an artificial thymic organoid system, researchers found that T cell differentiation occurred, implying a thymic defect, leading to the patient receiving an allogenic cultured thymus tissue implant, which showed promising signs of T cell development after 9 months.
View Article and Find Full Text PDF

Rosette-forming multicentric B-cell lymphoma in a giant panda.

J Vet Diagn Invest

November 2024

Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR, China.

Literature covering diseases of the giant panda () is either in Chinese or focuses on infectious agents. Here we describe the clinical signs, gross and microscopic findings, and immunohistochemistry results of a B-cell lymphoma in multiple organs of a 35-y-old captive male giant panda. The animal was euthanized because of prolonged anorexia and vomiting.

View Article and Find Full Text PDF

Purpose: Gallbladder carcinoma (GBC) poses significant challenges in oncology due to its aggressive nature and limited treatment options. The lack of effective biomarkers for early detection and prognosis exacerbates the prognosis for GBC patients. Tumor budding (TB) and tumor infiltrating lymphocytes (TILs) have emerged as potential prognostic indicators in various cancers, reflecting tumor-host immune interactions and tumor aggressiveness.

View Article and Find Full Text PDF

The historical control database of a multinational laboratory services provider was queried for all histopathologic findings in New Zealand White rabbits which were used as control animals during a ten-year period (2011-2020). The query included all evaluated tissues, with or without microscopic findings, in studies conducted for safety testing for regulatory approval by the U.S.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!