Purpose: The present study was attempted to probe into the relation between the genotype of Candida albicans and oral lichen planus, analyze the relativity of the genotype between commensal strains and pathogenic strains, to lay a good foundation for the prevention and treatment for candidiasis.
Methods: The present study adopted random amplified polymorphic DNA (RAPD) to analyze 46 Candida species which were isolated from the oral cavity of 9 health adults (N group) and the patients suffering from oral mucosal disease (including 16 lichen planus, LP group and 21 oral candidiasis, OC group).
Results: 40 strains were identified as Candida albicans. Different candida species emerged with different genetic types. The genotype of the OC group and N group were similar, genetic homology exits between OC group and N group. There was no distinct similarity in RAPD fingerprinting map of the LP group, which also had significant difference to the genotype of the N group (P<0.001). There was significant difference between OC group and LP group (P<0.001).
Conclusion: (1) The RAPD genotype not only can discriminate candida species, but also can distinguish further different types in the same species. (2) Oral candidiasis may originate from commensal strains. Candida albicans isolated from oral candidiasis were endogenous. (3) According to the results of genotypes, there might be no genetic homology between commensal strains and pathogenic strains in LP group. (4) The genotypes of pathogenic strains were not identical in different kinds of oral mucosa diseases.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Impact of Electronic and Conventional Cigarette Use towards Saliva Profile and Oral Microbiota in Adolescents.
Asian Pac J Cancer Prev
January 2025
Department of Rural Clinical Science, La Trobe Rural Health School, La Trobe University, Melbourne, Australia.
Objective: To compare the salivary profiles of smokers (e-cigarette smokers, e-cigarette and former conventional cigarette smokers, dual users, and conventional cigarette smokers) and non-smokers in adolescents, focusing on acidity level, flow rate, viscosity, as well as the quantity of Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans.
Methods: This analytical observational study, with a cross-sectional design, involves collecting saliva samples from five groups through the draining method. Saliva viscosity was assessed visually, while saliva flow rate was monitored over a ten-minute period.
Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during early biofilm formation.
Microbiol Spectr
January 2025
Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
a major human fungal pathogen, can form biofilms on a variety of inert and biological surfaces. biofilms allow for immune evasion, are highly resistant to antifungal therapies, and represent a significant complication for a wide variety of immunocompromised patients in clinical settings. While transcriptional regulators and global transcriptional profiles of biofilm formation have been well-characterized, much less is known about translational regulation of this important virulence property.
View Article and Find Full Text PDFVersatile applications of cobalt and copper complexes of biopolymeric Schiff base ligands derived from chitosan.
Int J Biol Macromol
January 2025
Catalytic Applications Laboratory, Department of Chemistry, School of Basic Sciences, Faculty of Science, Manipal University Jaipur, Dehmi Kalan, Jaipur 303007, Rajasthan, India. Electronic address:
In the present study, biopolymeric Schiff base (SB) ligands were synthesized from chitosan and isatin. Consequently, their earth abundant transition metal complexes of cobalt and copper were synthesized. All compounds were extensively characterized using FTIR and UV spectroscopy, thermo-gravimetric (TG) analysis, X-ray powder diffraction (XRD) and FESEM (field emission scanning electron microscopy).
View Article and Find Full Text PDFCholesterol-terminated cationic lipidated oligomers (CLOs) as a new class of antifungals.
J Mater Chem B
January 2025
Drug Delivery, Disposition, and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville, VIC, 3052, Australia.
Infections caused by fungal pathogens are a global health problem, and have created an urgent need for new antimicrobial strategies. This report details the synthesis of lipidated 2-vinyl-4,4-dimethyl-5-oxazolone (VDM) oligomers an optimized Cu(0)-mediated reversible-deactivation radical polymerization (RDRP) approach. Cholesterol-Br was used as an initiator to synthesize a library of oligo-VDM (degree of polymerisation = 5, 10, 15, 20, and 25), with an α-terminal cholesterol group.
View Article and Find Full Text PDFDendritic Antifungal Peptides as Potent Agents against Drug-Resistant and Biofilm.
J Med Chem
January 2025
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, P. R. China.
infection is a major public health problem, exacerbated by the emergence of drug-resistant fungi with the widespread use of antifungal drugs. Therefore, the development of novel antifungal drugs for drug-resistant infections is crucial. We constructed a series of dendritic antifungal peptides (AFPs) with different chain lengths of fatty acids as hydrophobic ends and 2 or 3 protease-stable repeats (Arg-Pro) as dendritic peptide branches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!