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Baseline Anal Sphincter Elastance May Predict Long-Term Outcomes of Sacral Neuromodulation for Fecal Incontinence.
J Surg Res
December 2024
Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK; Department of Colorectal Surgery, Manchester University NHS Foundation Trust, Manchester, UK.
Introduction: Anal acoustic reflectometry (AAR), a novel test of anal sphincter function, was shown to predict a successful trial phase of sacral neuromodulation (SNM) for fecal incontinence. This follow-up study aims to explore if AAR can also predict short- and long-term SNM outcomes at less than and more than 5 y, respectively.
Methods: Outcome data were reviewed from a prospectively managed database.
Factors Influencing Patient Enrollment in a Community-based Physical Activity Program After Healthcare Provider Referral: A Mixed Methods Study.
J Prim Care Community Health
December 2024
Temple University, Philadelphia, PA, USA.
Introduction And Objectives: Structured physical activity (PA) programs help to prevent and manage chronic diseases, yet systematic approaches to identify and enroll patients in these programs are lacking. Exercise is Medicine Greenville (EIMG) is a novel clinic-to-community model that identifies patients with chronic diseases in primary care settings and connects them to a structured, evidence-informed, community-based PA program. This study assessed influences on PA program enrollment using a mixed methods design.
View Article and Find Full Text PDFComparative evaluation of a novel [F] F-Labeled PET tracer XTR004 against [N] ammonia in myocardial perfusion imaging for coronary artery disease.
Eur J Nucl Med Mol Imaging
December 2024
Department of Nuclear Medicine, Peking Union Medical College Hospital. Chinese Academy of Medical Science & Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Aims: This study aimed to evaluate image quality, myocardial perfusion, and diagnostic performance of a novel [F]F-labeled PET tracer, XTR004 PET, myocardial perfusion imaging (MPI) compared with [N]Ammonia (NH) PET MPI.
Methods And Results: Forty-seven patients with suspected or known coronary artery disease (CAD) were prospectively enrolled to undergo one-day rest/ATP-stress XTR004 and NH electrocardiograph-gated PET imaging within 2 weeks. Among them, twenty-six patients underwent invasive coronary angiography (ICA), and nineteen were identified with flow-limited CAD (stenosis ≥ 70%).
Novel Use of an Aseptically Processed Amnion-Chorion Placental Allograft to Complement Wound Closure in High-Risk Sternotomy Patients: Clinical Safety and Outcomes.
Cureus
November 2024
Department of Research, MTF Biologics, Edison, USA.
Objectives Wound dehiscence is defined as the partial or complete separation of the layers of a surgical wound. Wound dehiscence and infections are of significant concern in the field of surgery as they can lead to a range of complications, including infection, delayed healing, increased healthcare costs, and patient discomfort. For patients at high risk of sternal wound dehiscence and infection, optimization of wound closure is critical.
View Article and Find Full Text PDFExosomal ETV4 Derived From M2 Macrophages Induces Growth, Glycolysis and Stemness in Hepatocellular Carcinoma by UpRegulating SULT2B1 Expression.
Liver Int
December 2024
Department of Hepatopancreatobiliary Surgery, Cancer Hospital of Shantou University Medical College, Shantou City, Guangdong, China.
Background: M2 macrophage-derived exosomes have been identified to modulate hepatocellular carcinoma (HCC) progression. E-twenty-six (ETS) variant transcription factor 4 (ETV4) shows protumoral effects in HCC. Here, we aimed to probe whether ETV4 performed oncogenic effects on HCC by macrophage-derived exosomes and its associated mechanism.
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