AI Article Synopsis
- - Our study evaluated the effectiveness of high-dose chemotherapy (HD-CT) compared to conventional chemotherapy (CT) for patients with metastatic breast cancer, involving 61 patients from 1992 to 1996.
- - Results showed that patients receiving HD-CT had a median time to progression (TTP) of 12 months, significantly better than the 6 months for the standard CT group, with lower relapse rates at both 2 and 5 years.
- - The median overall survival (OS) was also longer for HD-CT patients, with 44.1 months compared to 19.3 months for standard CT, suggesting HD-CT may improve patient outcomes, but more research is required to confirm its long
Article Abstract
The aim of our study was to evaluate the impact on time to progression (TTP) and overall survival (OS) of high-dose chemotherapy (HD-CT) over conventional CT in metastatic breast cancer patients. Between 09/92 and 12/96, 61 patients with chemosensitive metastatic breast cancer were randomised between HD-CT using the CMA regimen (Mitoxantrone, Cyclophosphamide, Melphalan) applied as consolidation (32 patients) or maintenance CT (29 patients). At randomisation, 13 patients were in complete response, 47 in partial response and one had stable disease. The median TTPs from randomisation were 6 and 12 months in the standard and intensive groups, respectively (P < 0.0056), with a relapse rate of 86.2% vs. 62.5% at 2 years, and 100% vs. 81.3% at 5 years. The median OS times were 19.3 and 44.1 months, with an OS rate of 13.8% vs. 36.8% at 5 years (P < 0.0294). The CMA regimen could prolong the TTP of patients with chemosensitive metastatic breast cancer. Further studies are needed to determine if this translates into an effect on OS.
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| http://dx.doi.org/10.1016/j.ejca.2004.09.006 | DOI Listing |
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