Marine n-3 polyunsaturated fatty acids and coronary heart disease. Part I. Background, epidemiology, animal data, effects on risk factors and safety.

In this paper, we will give an overview of the background for the possible effects of long-chain marine n-3 (synonymously called omega-3) polyunsaturated fatty acids (PUFA) in coronary heart disease (CHD) with focus on recent findings. In a forthcoming paper, we will focus on the clinical trial data, current recommendations and suggest trials to further study the role of marine n-3 PUFA in the prevention and treatment of CHD.