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Studies on the Stereoselective Synthesis of Sacubitril via a Chiral Amine Transfer Approach.
Chem Asian J
December 2024
CSIR National Chemical Laboratory, Center for Materials Characterization, INDIA.
We present a comprehensive account of our efforts directed towards the synthesis of sacubitril, a neprilysin inhibitor used in combination with valsartan and marketed as Entresto™. Our initial approach to the formal synthesis of sacubitril employed a chiral pool strategy, utilizing (S)-pyroglutamic acid as a key building block and Cu(I)-mediated Csp2-Csp3 cross-coupling as a key transformation. Further investigations led to the development of chiral amine transfer (CAT) reagents-based stereoselective synthesis.
View Article and Find Full Text PDFSingle-Carbon Insertion into Single C-C Bonds with Diazirines.
J Am Chem Soc
December 2024
Institute of Chemical Research of Catalonia (ICIQ-CERCA), The Barcelona Institute of Science and Technology, Països Catalans 16, 43007 Tarragona, Spain.
A novel platform for the skeletal editing of single C-C bonds via a single-carbon insertion has been developed using diazirines. This strategy involves the photogeneration of arylchlorocarbenes as carbynoid species that undergo site-selective carbene insertion into tertiary C-H bonds and a subsequent Wagner-Meerwein rearrangement promoted by a silver salt. Our skeletal editing strategy based on a formal selective carbyne C-C bond insertion has been demonstrated in six core-to-core conversions, including linear and cyclic benzylic substrates, alkanes and late-stage functionalizations.
View Article and Find Full Text PDFFEM simulation of breast deformation with semi-fluid representation.
Int J Comput Assist Radiol Surg
December 2024
Institute of Systems and Information Engineering, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki, 305-8573, Japan.
Purpose: In image-guided surgery for breast cancer, the representation of the breast deformation between planning and surgery plays a key role. The breast deforms significantly and behaves as a fluid with some constraints. Concretely, the deep fat layer in the breast deforms fluidly due to its incomplete fixation to the chest wall, while the anchoring structures by fascia avoid excessive deformation.
View Article and Find Full Text PDFResonant third-harmonic generation driven by out-of-equilibrium electron dynamics in sodium-based near-zero index thin films.
Nanophotonics
May 2024
Department of Physical and Chemical Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
We investigate resonant third-harmonic generation in near-zero index thin films driven out-of-equilibrium by intense optical excitation. Adopting the Landau weak coupling formalism to incorporate electron-electron and electron-phonon scattering processes, we derive a novel set of hydrodynamic equations accounting for collision-driven nonlinear dynamics in sodium. By perturbatively solving hydrodynamic equations, we model third-harmonic generation by a thin sodium film, finding that such a nonlinear process is resonant at the near-zero index resonance of the third-harmonic signal.
View Article and Find Full Text PDFEntangled photon-pair generation in nonlinear thin-films.
Nanophotonics
August 2024
Institute of Applied Physics, Abbe Center of Photonics, Friedrich Schiller University Jena, Albert-Einstein-Str. 15, 07745 Jena, Germany.
We develop a fully vectorial and non-paraxial formalism to describe spontaneous parametric down-conversion in nonlinear thin films. The formalism is capable of treating slabs with a sub-wavelength thickness, describe the associated Fabry-Pérot effects, and even treat absorptive nonlinear materials. With this formalism, we perform an in-depth study of the dynamics of entangled photon-pair generation in nonlinear thin films, to provide a needed theoretical understanding for such systems that have recently attracted much experimental attention as sources of photon pairs.
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