Specific interaction between human IgM and polyclonal antibodies immobilized on support was studied by atomic force microscopy. Human IgMs are responsible for a number of side effects arising during the xenotransplantation of mammalian organs to man. On the basis of atomic force microscopy, a quantitative analysis of complexes with IgM was performed. The data of the analysis agree well with the results of enzyme immunoassay. It was shown that the method of detection of immune complexes based on atomic force microscopy is able to detect specific antibodies/antigens in serum.
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Background: Previous studies have suggested that changes in the composition of the extracellular matrix (ECM) play a significant role in the development of ligamentum flavum hypertrophy (LFH) and the histological differences between the ventral and dorsal layers of the hypertrophied ligamentum flavum. Although LFH is associated with increased fibrosis in the dorsal layer, comprehensive research exploring the characteristics of the ECM and its mechanical properties in both regions is limited. Furthermore, the distribution of fibrosis-associated myofibroblasts within LFH remains poorly understood.
View Article and Find Full Text PDFAl doped silica glass: investigation of structural response and defect interactions based on crystalline models.
Phys Chem Chem Phys
January 2025
The Quartz Corp, Hellandsveien 14, 8270, Drag, Norway.
High purity quartz glass is an important material in high-tech industries like semiconductors and photovoltaics due to, among other properties, its good mechanical performance at high temperatures. Small amounts of Al in silica glass (in the range between 20 ppm and 100 ppm) have previously been shown to increase the viscosity of the SiO glass. The underlying mechanism for this increase is, however, not well understood.
View Article and Find Full Text PDFThe antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.
BMC Oral Health
January 2025
Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
Background: To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material.
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Comparing four different methods of measuring fracture toughness and its relationship with fractal dimension in a polycrystalline (3Y-TZP) dental ceramic.
Dent Mater
January 2025
Department of Biomedical Materials Science, University of Mississippi Medical Center, 2500 North State Street, Room D528, Jackson, MS 39216-4505, USA. Electronic address:
Objectives: Previous studies reported various methods of measuring fracture toughness of dental ceramics. The objectives of this study were to compare different methods and to validate fractal analysis to estimate fracture toughness for a polycrystalline dental ceramic.
Methods: Bar-shaped specimens were prepared from 3 mol% yttria-stabilized tetragonal polycrystalline (3Y-TZP) ceramic.
Physicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps.
ACS Appl Mater Interfaces
January 2025
University of California, Berkeley─University of California, San Francisco Graduate Program in Bioengineering, San Francisco, California 94158, United States.
Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause an exacerbated hyperinflammatory response in a variety of diseases and can lead to host tissue damage without clearance of infection. Nanoparticle drug delivery is a promising avenue for creating materials that can both target NETs and deliver sustained amounts of NET-degrading drugs to alleviate hyperinflammation.
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