Purpose: To study factors associated with discontinuation of antiepileptic drugs (AEDs) in idiopathic generalized epilepsy (IGE) and symptomatic/cryptogenic localization-related epilepsy (S/CLRE) METHODS: For the IGE study, 71 patients who were able to discontinue their AED (discontinued-IGE group) were compared to 71 patients who continued AED therapy (continued-IGE group) and 20 patients with seizure relapse after discontinuing AED (relapsed-IGE group). For S/CLRE, 90 patients who were able to discontinue AED (discontinued-S/CLRE group) were compared to 90 patients who continued AED (continued-S/CLRE group) and 76 patients with benign childhood epilepsy with centrotemporal spikes who were able to discontinue AED (discontinued-BECTS group).
Results: Compared to the continued-IGE group, the discontinued-IGE group showed a weaker seizure propensity, better response to AEDs, more frequent epileptiform discharge suppression, and lower frequency of generalized tonic-clonic seizures (GTCs). Compared to the relapse-IGE group, the discontinued-IGE group had more frequent epileptiform discharge suppression. The discontinued-S/CLRE group showed a weaker seizure propensity, better response to AEDs, more frequent epileptiform discharge suppression, and less frequent symptomatic signs compared to the continued-S/C LRE group. Notably, the age at epilepsy onset was not a critical factor for discontinuing AEDs in both IGE and S/CLRE. Although the discontinued-S/CLRE group had more frequent symptomatic signs, older age at epilepsy onset and less frequent epileptiform discharge suppression than the discontinued-BECTS group, no difference was found in seizure propensity and response to AEDs between the two groups.
Conclusions: Seizure propensity, epileptiform discharge, and response to AEDs should be considered to predict the possibility of terminating AED therapy in IGE or S/CLRE. In addition, attention should be paid to seizure pattern in IGE and symptomatic signs in LRE.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.0013-9580.2004.458006.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diurnal dynamics of the Zbtb14 protein in the ventral hippocampus are disrupted in epileptic mice.
Neuroscience
January 2025
Laboratory of Epileptogenesis, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur St, 02-093 Warsaw, Poland. Electronic address:
Our previous in silico data indicated an overrepresentation of the ZF5 motif in the promoters of genes in which circadian oscillations are altered in the ventral hippocampus in the pilocarpine model of temporal lobe epilepsy in mice. In this study, we test the hypothesis that the Zbtb14 protein oscillates in the hippocampus in a diurnal manner and that this oscillation is disrupted by epilepsy. We found that Zbtb14 immunostaining is present in the cytoplasm and cell nuclei.
View Article and Find Full Text PDFEEG-to-EEG: Scalp-to-Intracranial EEG Translation Using a Combination of Variational Autoencoder and Generative Adversarial Networks.
Sensors (Basel)
January 2025
Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ, UK.
A generative adversarial network (GAN) makes it possible to map a data sample from one domain to another one. It has extensively been employed in image-to-image and text-to image translation. We propose an EEG-to-EEG translation model to map the scalp-mounted EEG (scEEG) sensor signals to intracranial EEG (iEEG) sensor signals recorded by foramen ovale sensors inserted into the brain.
View Article and Find Full Text PDFEEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.
J Clin Med
January 2025
Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, 56128 Pisa, Italy.
The literature suggests the existence of an association between autism spectrum disorders (ASDs) and subclinical electroencephalographic abnormalities (SEAs), which show a heterogeneous prevalence rate (12.5-60.7%) within the pediatric ASD population.
View Article and Find Full Text PDFSpatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro.
Prog Neurobiol
January 2025
Institute of Biomedical Investigations August Pi i Sunyer (IDIBAPS), Systems Neuroscience, 08036 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address:
Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from cortical slices of neocortical tissue from refractory epilepsy patients. Multi-electrode recordings were combined with histological information, providing a two-dimensional spatiotemporal characterization of human cortical dynamics in control conditions and following modulation of the excitation/inhibition balance.
View Article and Find Full Text PDFModulation of in vitro Network Activity by Optogenetic Stimulation of Parvalbumin-positive Interneurons During Estrous Cycle.
Curr Neuropharmacol
January 2025
Departments of Neurology & Neurosurgery, and Physiology, Montreal Neurological Institute-Hospital, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.
Background: Catamenial epilepsy, which is defined as a periodicity of seizure exacerbation occurring during the menstrual cycle, has been reported in up to 70% of epileptic women. These seizures are often non-responsive to medication and our understanding of the relation between menstrual cycle and seizure generation (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!