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The Role of MA Modification in Autoimmunity: Emerging Mechanisms and Therapeutic Implications.
Clin Rev Allergy Immunol
March 2025
Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
N6-methyladenosine (mA), a prevalent and essential RNA modification, serves a key function in driving autoimmune disease pathogenesis. By modulating immune cell development, activation, migration, and polarization, as well as inflammatory pathways, mA is crucial in forming innate defenses and adaptive immunity. This article provides a comprehensive overview of mA modification features and reveals how its dysregulation affects the intensity and persistence of immune responses, disrupts immune tolerance, exacerbates tissue damage, and promotes the development of autoimmunity.
View Article and Find Full Text PDFMizoribine or Cyclophosphamide for Lupus Nephritis: A Randomized Clinical Trial.
JAMA Netw Open
March 2025
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
Importance: Lupus nephritis is typically treated with intravenous cyclophosphamide, which is associated with serious adverse effects. Oral mizoribine may be an alternative for induction therapy of lupus nephritis. However, large-scale, long-term, randomized clinical studies of mizoribine are lacking.
View Article and Find Full Text PDFNonsteroidal anti-inflammatory drugs (NSAIDs) for acute renal colic.
Cochrane Database Syst Rev
March 2025
Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
Background: Urolithiasis (urinary stones) is a common disease with an increasing incidence globally. It often presents with renal colic, which is characterised by acute and intense abdominal pain. The first step in the management of renal colic is pain control.
View Article and Find Full Text PDFN6-methyladenosine RNA modified BAIAP2L2 facilitates extracellular vesicles-mediated chemoresistance transmission in gastric cancer.
J Transl Med
March 2025
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: Extracellular vesicles (EVs) produced in the tumor microenvironment in response to chemotherapy promote chemotherapy-resistant phenotypes. However, the role of EVs proteins induced by gastric cancer (GC) cell chemotherapy in regulating chemotherapy resistance remains unclear.
Methods: Immunohistochemistry was used to verify the relationship between brain-specific angiogenesis inhibitor 1-associated protein-2-like protein 2 (BAIAP2L2) expression and chemotherapy resistance in advanced GC.
Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study.
J Headache Pain
March 2025
Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing, 100853, China.
Background: Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compared to those without MOH. However, prior studies, often limited to single imaging modalities, have yielded inconsistent findings. This study employs multimodal MRI-combining structural, diffusion tensor, and functional imaging-to characterize brain abnormalities in CM patients with and without MOH, while investigating the relationship between acute analgesic use frequency and these changes.
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