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ProtoNet 4.0: a hierarchical classification of one million protein sequences. | LitMetric

ProtoNet 4.0: a hierarchical classification of one million protein sequences.

Nucleic Acids Res

Department of Biological Chemistry, Institute of Life Sciences and School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel.

Published: January 2005

AI Article Synopsis

Article Abstract

ProtoNet is an automatic hierarchical classification of the protein sequence space. In 2004, the ProtoNet (version 4.0) presents the analysis of over one million proteins merged from SwissProt and TrEMBL databases. In addition to rich visualization and analysis tools to navigate the clustering hierarchy, we incorporated several improvements that allow a simplified view of the scaffold of the proteins. An unsupervised, biologically valid method that was developed resulted in a condensation of the ProtoNet hierarchy to only 12% of the clusters. A large portion of these clusters was automatically assigned high confidence biological names according to their correspondence with functional annotations. ProtoNet is available at: http://www.protonet.cs.huji.ac.il.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539961PMC
http://dx.doi.org/10.1093/nar/gki007DOI Listing

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