SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers.

Biochem Biophys Res Commun

Laboratoire de Physiologie Cellulaire et Moléculaire, CNRS UMR 6548, Faculté des Sciences, Parc Valrose, 06108 Nice Cedex 2, France.

Published: January 2005

With the aim of finding important mediators of muscle atrophy, we cloned SMHS1, a novel gene that was found to be upregulated in rat soleus muscle atrophied by restriction of activity. The SMHS1 amino acid sequence shares 65% similarity with RTP801-which is a cellular stress response protein regulated by HIF-1-but SMHS1 expression was demonstrated to be independent of HIF-1. SMHS1 was found to be mainly expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to the muscle energy metabolism phenotypes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2004.11.111DOI Listing

Publication Analysis

Top Keywords

smhs1
6
muscle
5
smhs1 involved
4
involved oxidative/glycolytic-energy
4
oxidative/glycolytic-energy metabolism
4
metabolism balance
4
balance muscle
4
muscle fibers
4
fibers aim
4
aim finding
4

Similar Publications

SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers.

Biochem Biophys Res Commun

January 2005

Laboratoire de Physiologie Cellulaire et Moléculaire, CNRS UMR 6548, Faculté des Sciences, Parc Valrose, 06108 Nice Cedex 2, France.

With the aim of finding important mediators of muscle atrophy, we cloned SMHS1, a novel gene that was found to be upregulated in rat soleus muscle atrophied by restriction of activity. The SMHS1 amino acid sequence shares 65% similarity with RTP801-which is a cellular stress response protein regulated by HIF-1-but SMHS1 expression was demonstrated to be independent of HIF-1. SMHS1 was found to be mainly expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to the muscle energy metabolism phenotypes.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!