AI Article Synopsis
- A rare brain infection caused by the neurotropic fungus Cladosporium bantianum is difficult to treat and frequently relapses even with standard antifungal medications like amphotericin B and flucytosine.
- Diagnosis is confirmed by isolating the fungus from tissue samples and noting the characteristic dark-colored fungal colonies.
- This report discusses a case where intensive antifungal treatment successfully addressed the brain fungal granuloma, alongside a review of existing literature on the condition.
Article Abstract
Involvement of the brain by neurotropic, dematiaceous fungi namely Cladosporium bantianum is extremely rare. The disease is very resistant to treatment and prone for frequent relapses despite treatment with amphotericin B and flucytosine, the drugs of choice for the infection. Surgery is often required for resection of the fungal granuloma. Isolation of the fungus from the tissue specimens and its culture, showing dark colored fungal colonies clinches the diagnosis. Animal inoculation studies can provide insights to the portal of entry of the organism. We hereby report a case of fungal granuloma of the brain due to C. bantianum, which responded favorably to intensive antifungal treatment alone, with relevant review of literature.
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| http://dx.doi.org/10.1016/j.jns.2004.10.002 | DOI Listing |
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