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Assessing the efficacy and safety profiles of 0.025% tretinoin in treating axillary hyperpigmentation with acanthosis nigricans: a randomized double-blinded study.
Arch Dermatol Res
January 2025
Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, HRH Princess Maha Chakri Sirindhorn Medical Center, Rangsit- Nakhonnayok Road, Ongkharak, Nakhonnayok, 26120, Thailand.
Acanthosis nigricans (AN) is a dermatological condition, marked by hyperpigmentation and skin thickening, frequently affecting body folds like the axillae. Treatment options for axillary hyperpigmentation remain underexplored. This study evaluated the efficacy of 0.
View Article and Find Full Text PDFSafety and Efficacy of Trichloroacetic Acid Peels in the Treatment of Melasma: A Split-face, Randomized, Prospective Trial in Latin American Women.
J Clin Aesthet Dermatol
September 2024
Drs. Lorenzo-Rios, Arias Berrios, and Brau Javier are with the Department of Dermatology at the University of Puerto Rico School of Medicine in San Juan, Puerto Rico.
Article Synopsis
- - There is ongoing debate regarding the effectiveness and safety of chemical peels for treating melasma in Hispanic women, with previous studies being limited by various methodological flaws.
- - This study aimed to assess how safe and effective trichloroacetic acid (TCA) peels, when combined with hydroquinone and tretinoin, are for treating melasma in Hispanic women through a controlled prospective trial.
- - Results showed that TCA peels significantly improved melasma severity compared to just using hydroquinone and tretinoin, suggesting that TCA peels are a beneficial addition to treatment for this demographic.
Introduction: Chronic exposure to ultraviolet light photoages skin. Retinol, a precursor molecule to retinoic acid that causes less irritation, is available as a nonprescription, cosmetic retinoid and improves collagen production, skin elasticity, and signs of photoaging. Advances in formulation science have allowed the production of stabilized bioactive retinol formulations.
View Article and Find Full Text PDFLiposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability.
Pharmaceutics
February 2024
Dermatology Department, University of California, San Francisco, CA 94143-0989, USA.
Acne vulgaris is a common dermatologic disorder that affects approximately 85% of teenagers, which significantly impacts the quality of life in adolescents. It is a chronic disease of the sebaceous follicles that is multifactorial in etiology. Topical treatment is the first choice for mild and moderate acne, while systemic therapy is reserved for severe and certain moderate cases.
View Article and Find Full Text PDFComparison of efficacy and safety of tretinoin 0.05% and glycolic acid peeling 70% in axillary and neck lesions of acanthosis nigricans: A single-blinded, randomized trial.
J Cosmet Dermatol
June 2024
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Acanthosis nigricans is a skin disorder causing dark, velvety patches, mainly in the neck and armpits, often linked to obesity and insulin resistance; it raises cosmetic concerns prompting treatment.
- This study compared the effectiveness and side effects of two treatments: tretinoin 0.05% used every other night and glycolic acid 70% applied bi-weekly for 8 weeks, focusing on neck and axillary lesions.
- Results showed tretinoin was significantly more effective for axillary lesions, enhancing treatment response and patient satisfaction, while neither treatment effectively addressed neck lesions.
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