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Article Synopsis
- The LightFix Trial aimed to assess the effectiveness of the IlluminOss System (IS) in treating impending and completed pathological fractures of the humerus over one year.
- A study with 81 patients showed significant decreases in pain and increases in upper limb function after treatment, with notable improvements in pain scores and functional metrics throughout the year.
- While the IS provided benefits, it had a device fracture rate of 15%, suggesting caution when used alone for completed fractures.
Bilateral Atypical Femoral Fracture in a Bisphosphonate-Naïve Patient with Prior Long-Term Denosumab Therapy: A Case Report of the Management Strategy and a Literature Review.
J Clin Med
May 2024
Division of Orthopaedic Trauma & Adult Reconstruction, Department of Orthopaedic Surgery, Cooperman Barnabas Medical Center-RWJBarnabas Health, Livingston, NJ 07039, USA.
Article Synopsis
- Denosumab is an effective treatment for preventing fractures, but its link to atypical femur fractures (AFFs) in patients who haven't used bisphosphonates is not well understood.
- A case report highlights a 78-year-old woman who experienced bilateral AFFs after long-term denosumab therapy for metastatic breast cancer, prompting the need to stop the medication.
- The report stresses the importance of doctors being vigilant in monitoring patients on denosumab for signs of AFFs and calls for more research to improve treatment strategies that weigh its benefits against associated risks.
Quorum-sensing system of primes gene expression for protection from lethal oxidative stress.
Elife
April 2024
Department of Medicine, Division of Infectious Diseases, NYU Grossman School of Medicine, New York, United States.
The quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of HO, a crucial host defense against . We now report that protection by surprisingly extends beyond post-exponential growth to the exit from stationary phase when the system is no longer turned on. Thus, can be considered a constitutive protective factor.
View Article and Find Full Text PDFBrain abscesses following carotid blowout syndrome: a case report.
Radiol Case Rep
April 2024
Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
We report a case of intracranial abscesses development in a patient with head and neck cancer after emergent treatment of carotid blowout syndrome with coil embolization. Our patient is a 60-year-old male who presented with hemoptysis and hematemesis, which raised concerns for impending carotid blowout syndrome. Endovascular occlusion was successfully achieved, and the patient was discharged in stable condition.
View Article and Find Full Text PDFMako robotic-arm-assisted total hip and total knee arthroplasty outcomes in an orthopedic oncology setting: A case series.
J Orthop
December 2023
Department of Orthopedic Surgery Morristown Medical Center, Morristown, NJ, USA.
Background: The MAKO Robotic-Arm system is a cutting-edge technology which combines both computed tomography (CT) scanning and three-dimensional planning to determine the ideal size and orientation of implants prior to bone resection. It is typically utilized within a general orthopedic setting for joint replacement procedures, such as total joint arthroplasties. However, its use within orthopedic oncology, which contains a much more compromised patient population and more complex surgical treatment, is not well documented within the literature.
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