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Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model.
Front Transplant
December 2024
Duke Transplant Center, Duke University School of Medicine, Durham, NC, United States.
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR, however PI-associated toxicity limits their therapeutic utility. Novel immunoproteasome inhibitors (IPIs) have higher specificity for immune cells and have not been investigated for AMR in cardiac transplant patients.
View Article and Find Full Text PDFSystemic treatment among frail older patients with cancer: An observational cohort.
J Geriatr Oncol
December 2024
Medical Oncology Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France. Electronic address:
Introduction: In the past, certain oncological therapies were not offered to frail older patients. However, the advancement of geriatric oncology, tailored chemotherapy regimens, the introduction of new treatments, and the optimization of supportive care have contributed to enhancing the therapeutic margin. We aimed to evaluate the benefit of systemic treatment among older adults by assessing the three-month survival of older frail patients with metastatic cancer.
View Article and Find Full Text PDFManagement of Petrous and Tentorial Dural Arteriovenous Fistulas: A Systematic Review.
Cureus
November 2024
Department of Surgery, Baghdad Teaching Hospital, Medical City Complex, Baghdad, IRQ.
The petrous and tentorial dural arteriovenous fistulas are vascular malformations that are very infrequent but highly aggressive, with a significant risk of intracranial hemorrhage and neurological deficits. Optimal management remains one of the most debated subjects, with various series reporting endovascular and microsurgical approaches. Therefore, this systematic review aims to assess the efficacy, safety, and outcomes of different treatment modalities of petrous and tentorial dural arteriovenous fistulas (DAVFs) based on clinical presentation, imaging techniques, treatment outcome, and complications arising in the course of their treatment.
View Article and Find Full Text PDFTransabdominal sac puncture: A straightforward access to an excluded iliac artery aneurysm.
J Vasc Access
December 2024
Radiology Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Iliac artery aneurysms (IAA) associated with abdominal aortic aneurysms (AAA) are found in 10%-20% of AAAs. Isolated internal iliac artery aneurysms (IIAAs) are an uncommon entity, representing 0.3%-0.
View Article and Find Full Text PDFA "Mismatched" connection: a rare case of indirect or dural carotid-cavernous fistula: a case based review.
Ann Med Surg (Lond)
December 2024
Department of Neurosurgery, Neurosurgery Clinic, Birgunj, Nepal.
Introduction And Importance: A carotid-cavernous sinus fistula is an abnormal connection between the internal or external carotid artery and the venous system of the cavernous sinus. It represents a rare entity, and it is often misdiagnosed due to its overlapping symptoms with other conditions such as cavernous sinus thrombosis or orbital inflammation. Cerebral angiography continues to be the gold standard for diagnosis and surgical planning in patients with CCF, and the endovascular trans-venous approach still represents the primary line of treatment.
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