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Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?
J Neuroinflammation
July 2024
Oasi Research Institute-IRCCS, 94018, Troina, Italy.
Article Synopsis
- Recent drugs for Alzheimer's disease have not worked well and can cause serious problems.
- Scientists are looking at how inflammation in the brain might be linked to Alzheimer's and how it changes over time.
- New blood tests could help doctors understand Alzheimer's better and match treatments to individual patients based on their specific symptoms.
Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes.
J Cancer Res Ther
November 2023
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, India.
Background: Head-and-neck squamous cell carcinoma is associated with the epigenetic silencing of various genes such as DAPK, ataxia telangiectasia mutated (ATM), BRCA1, p16, pVHL, p16, and RASSF1A. The most common epigenetic change observed in these genes is DNA methylation that directs the studies toward finding inhibitors for DNA methyltransferases (DNMTs), the protagonist in the action. The present study focuses on analyzing the possibility whether indole curcumin can reverse epigenetic changes of the various tumor suppressor genes, characteristically silenced by methylation, by inhibiting the major methylation enzyme DNA methyltransferase 1 or DNMT1.
View Article and Find Full Text PDFMulticenter Preparedness Exercise Enables Rapid Development of Cluster-Specific PCR-Based Screening Assays from Bacterial Genomic Data.
J Clin Microbiol
March 2023
Institute of Hygiene, University Hospital Münster, Münster, Germany.
PCR-based screening assays targeting strain-specific genetic markers allow the timely detection and specific differentiation of bacterial strains. Especially in situations where an infection cluster occurs, fast assay development is crucial for supporting targeted control measures. However, the turnaround times (TATs) for assay setup may be high due to insufficient knowledge about screening assay methods, workflows, and software tools.
View Article and Find Full Text PDFThe AMR-ARRAY: A modular bead array detecting β-lactam, (fluoro) quinolone, colistin, aminoglycoside and macrolide resistance determinants in Gram-negative bacteria.
J Microbiol Methods
May 2022
Veterinary Bacteriology, Sciensano, Ixelles, Belgium. Electronic address:
The aim of this study was to develop a highly multiplexed bead array to detect genes and/or mutations frequently associated with resistance to antimicrobials of the β-lactam, (fluoro)quinolone, colistin, macrolide and aminoglycoside families in Enterobacteriaceae such as Escherichia coli, Shigella spp. and Salmonella spp. Ligase Chain Reaction and the Luminex® technology were combined in a 53-plex assay designed to target selected genetic markers with 3 internal controls.
View Article and Find Full Text PDFPolymorphic and Higher-Order G-Quadruplexes as Possible Transcription Regulators: Novel Perspectives for Future Anticancer Therapeutic Applications.
Pharmaceuticals (Basel)
March 2022
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Marzolo 5, 35131 Padova, Italy.
In the past two decades, significant efforts have been put into designing small molecules to target selected genomic sites where DNA conformational rearrangements control gene expression. G-rich sequences at oncogene promoters are considered good points of intervention since, under specific environmental conditions, they can fold into non-canonical tetrahelical structures known as G-quadruplexes. However, emerging evidence points to a frequent lack of correlation between small molecule targeting of G-quadruplexes at gene promoters and the expression of the associated protein, which hampers pharmaceutical applications.
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