AI Article Synopsis
- The study compared the duration of protection against bronchoconstriction from inhaled salmeterol (50 and 100 micrograms) and salbutamol (200 micrograms) in 12 asthma patients.
- Salbutamol's bronchodilating effect lasted around 4 hours, while salmeterol maintained significant protection for at least 12 hours.
- Some patients experienced tremors and palpitations after using the higher dose of salmeterol, but overall, salmeterol showed a much longer-lasting benefit.
Article Abstract
The duration of the protective effect of 50 and 100 micrograms of inhaled salmeterol against methacholine-induced bronchoconstriction was compared with that of 200 micrograms of inhaled salbutamol in 12 patients with asthma with a baseline FEV1 of at least 70% and a provocative concentration of inhaled methacholine causing a 20% fall in FEV1 (PC20) greater than or equal to 8 mg/ml. The study was placebo controlled, double blind, randomized, and crossover. The bronchodilating effect was no longer significant 4 hours after inhalation of salbutamol, whereas the effect was still present 12 hours after administration of 50 and 100 micrograms of salmeterol. All active treatments caused PC20 to increase at 1 hour (p less than 0.05). PC20 (milligrams per milliliter) thus reached 3.7 +/- 0.8 after placebo, 13.8 +/- 3.0 after 50 micrograms of salmeterol, 23.2 +/- 4.7 after 100 micrograms of salmeterol, and 13.9 +/- 3.4 after 200 micrograms of salbutamol. The protective effect of 200 micrograms of salbutamol was no longer significant at 4 hours, whereas both doses of salmeterol protected against methacholine challenge up to 12 hours after inhalation (p less than 0.01). An increased incidence of tremor (2/12) and palpitations (2/12) was recorded after inhalation of 100 micrograms of salmeterol. We conclude that inhalation of 50 or 100 micrograms of salmeterol causes a long-lasting bronchodilatation and protects against methacholine-induced bronchoconstriction for at least 12 hours.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0091-6749(92)90435-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers.
Nat Commun
January 2025
Replicate Bioscience Inc, San Diego, CA, USA.
Self-replicating RNA (srRNA) technology, in comparison to mRNA vaccines, has shown dose-sparing by approximately 10-fold and more durable immune responses. However, no improvements are observed in the adverse events profile. Here, we develop an srRNA vaccine platform with optimized non-coding regions and demonstrate immunogenicity and safety in preclinical and clinical development.
View Article and Find Full Text PDFDevelopment and biochemical characterization of freeze-dried guava powder fortified with Lactobacillus plantarum.
J Food Sci
December 2024
Department of Food Science & Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
Guava (Psidium guajava L.) is one of the most nutrient-dense fruits, which is native to tropical and subtropical regions of the world. The processing of value-added products from guava has not been carried out on a scale similar to some other fruits, which offers an opportunity to fully exploit the potential of this fruit, such as guava-based nutraceutical food products.
View Article and Find Full Text PDFMultiple Displacement Amplification Facilitates SMRT Sequencing of Microscopic Animals and the Genome of the Gastrotrich Lepidodermella squamata (Dujardin 1841).
Genome Biol Evol
December 2024
Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama, USA.
Obtaining adequate DNA for long-read genome sequencing remains a roadblock to producing contiguous genomes from small-bodied organisms, hindering understanding of phylogenetic relationships and genome evolution. Multiple displacement amplification leverages Phi29 DNA polymerase to produce micrograms of DNA from picograms of input. However, multiple displacement amplification's inherent biases in amplification related to guanine and cytosine (GC) content, repeat content and chimera production are a problem for long-read genome assembly, which has been little investigated.
View Article and Find Full Text PDFOn-The-Flight trapping, LIBS analysis and discrimination of single meteorite particles generated by laser ablation.
Anal Chim Acta
December 2024
UMALASERLAB, Departamento de Química Analítica, Universidad de Málaga, C/Jiménez Fraud 4, Malaga, 29010, Spain. Electronic address:
Background: Thousands of micrometeorites fall to the Earth on a daily basis. Most of these meteorites have a rocky composition, but others are mainly composed of iron and nickel. Due to their small size, often ca.
View Article and Find Full Text PDFA follow-up study with a double-blinded, randomized controlled vitamin D supplementation trial in patients with major depressive episode (DepFuD): A study protocol and baseline characteristics.
Food Sci Nutr
October 2024
Mental Health and Wellbeing, Kuopio University Hospital Wellbeing Services County of North Savo Kuopio Finland.
Promising initial studies on vitamin D (VD) supplementation as an adjunct treatment for major depressive disorder (MDD) require rigorously designed randomized controlled trials (RCTs). We aim to investigate the effects of augmenting standard MDD treatment with VD supplementation and examine factors influencing the treatment outcome. This article describes the study design, measures, and baseline characteristics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!