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Early life environmental enrichment yields resilience to selected behavioural and brain responses to 5-fluorouracil in mice.
Brain Behav Immun
January 2025
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong; Mental Health Research Centre, The Hong Kong Polytechnic University, Hong Kong. Electronic address:
Chemotherapy remains the primary treatment modality for multiple cancer types, but the cytotoxicity of chemotherapeutic drugs often leads to persistent psychological disturbances that undermine daily function. Minimizing such unwanted effects is challenging in the rehabilitation/prehabilitation of cancer survivors, hence the impetus to identify modifiable external factors capable of improving the recovery process. The importance of social stimulation has been demonstrated in a mouse model showing that grouped housing lowered the likelihood of developing mood disturbance following exposure to chemotherapeutic drugs compared with isolated housing.
View Article and Find Full Text PDFPaying for home care out-of-pocket is common and costly across the income spectrum among older adults.
Health Aff Sch
January 2025
Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Many older adults with personal care needs rely on paid caregivers to remain in the community ("home care"). Those without Medicaid or private long-term-care insurance must pay out-of-pocket for care. We used the Health and Retirement Study to identify the prevalence and financial burden of paying for home care out-of-pocket in 2002-2018, by income and dementia status.
View Article and Find Full Text PDFNew Challenges in Bladder Cancer Diagnosis: How Biosensing Tools Can Lead to Population Screening Opportunities.
Sensors (Basel)
December 2024
Institute of Genetics and Biophysics "A. Buzzati Traverso", National Research Council (CNR), 80131 Naples, Italy.
Bladder cancer is one of the most common cancers worldwide. Despite its high incidence, cystoscopy remains the currently used diagnostic gold standard, although it is invasive, expensive and has low sensitivity. As a result, the cancer diagnosis is mostly late, as it occurs following the presence of hematuria in urine, and population screening is not allowed.
View Article and Find Full Text PDFMidwives' and nurses' experiences of providing postnatal care in partnership: A cross-sectional study.
Women Birth
January 2025
Department of Nursing and Midwifery Education and Research, King Edward Memorial Hospital, Subiaco, Australia; School of Nursing, Curtin University, Bentley, Australia.
Problem: It is unknown whether the deployment of registered nurses to assist midwives in the provision of postnatal care eases the burden of workforce shortages.
Background: The largest public maternity health service in Western Australia began employing registered nurses in 2022 to assist midwives with the provision of postnatal care on maternity wards in response to staffing shortages, exacerbated by COVID-19.
Aim: To explore midwives' and registered nurses' experiences of providing postnatal care on maternity wards together.
An updated overview on long-acting therapeutics for the prevention and treatment of human immunodeficiency virus (HIV) from a perspective of pharmaceutics.
Int J Pharm
December 2024
Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address:
Conventional drug formulations release active pharmaceutical ingredients (APIs) immediately after administration, while long-acting (LA) drug products are designed for prolonged therapeutic effects, thereby reducing administration frequency and improving patient compliance. The development of LA therapeutics for chronic disease treatment has significantly helped patients adhere to their regimens, reducing the need for daily doses and easing the burden on healthcare systems. Advances in treatment have transformed Human Immunodeficiency Virus (HIV) into a manageable chronic disease, and efforts are underway to eliminate HIV in the future.
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