Fordyce granules are found in the oral mucosa of up to 80% of adults. However, primary malignant sebaceous tumors of the oral mucosa are exceedingly rare. To our knowledge, only 5 examples of intraoral sebaceous carcinoma have been reported in the literature. This report describes a primary sebaceous carcinoma of the labial mucosa that arose in an area containing numerous Fordyce granules. A brief review of the clinical and histopathologic features of sebaceous carcinoma is also presented.
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