Magnetic resonance imaging was used to measure the hippocampal and amygdalar volumes of 60 chimpanzees (Pan troglodytes). An asymmetry quotient (AQ) was then used to calculate the asymmetry for each of the structures. A one-sample t test indicated that there was a population-level right hemisphere asymmetry for the hippocampus. There was no significant population-level asymmetry for the amygdala. An analysis of variance using sex and rearing history as between-group variables showed no significant main effects or interaction effects on the AQ scores; however, males were more strongly lateralized than females. Several of these findings are consistent with results found in the human literature.
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http://dx.doi.org/10.1037/0735-7044.118.6.1460 | DOI Listing |
Sci Rep
January 2025
Laboratory for Regenerative Biology, National Institute for Basic Biology, Okazaki, Aichi, Japan.
Analysis of genome-scale evolution has been difficult in large, endangered animals because opportunities to collect high-quality genetic samples are limited. There is a need for novel field-friendly, cost-effective genetic techniques. This study conducted an exome-wide analysis of a total of 42 chimpanzees (Pan troglodytes) across six African regions, providing insights into population discrimination techniques.
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January 2025
School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9AJ, UK.
Chimpanzees excel at inference tasks which require that they search for a single food item from partial information. Yet, when presented with 2-item tasks which test the same inference operation, chimpanzees show a consistent breakdown in performance. Here we test a diverse zoo-housed cohort (n = 24) comprising all 4 great ape species under the classic 4-cup 2-item task, previously administered to children and chimpanzees, and a modified task administered to baboons.
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December 2024
The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Ave., Maywood, IL, 60153, USA.
Designing and carrying out a controlled human infection (CHI) model for hepatitis C virus (HCV) is critical for vaccine development. However, key considerations for a CHI model protocol include understanding of the earliest viral-host kinetic events during the acute phase and susceptibility of the viral isolate under consideration for use in the CHI model to antiviral treatment before any infections in human volunteers can take place. Humanized mouse models lack adaptive immune responses but provide a unique opportunity to obtain quantitative understanding of early HCV kinetics and develop mathematical models to further understand viral and innate immune response dynamics during acute HCV infection.
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December 2024
Graduate School of Human Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
Recent evidence indicates that human ancestors utilized a combination of quadrupedal walking, climbing, and bipedal walking. Therefore, the origin of bipedalism may be linked to underlying mechanisms supporting diverse locomotor modes. This study aimed to elucidate foundations of varied locomotor modes from the perspective of motor control by identifying muscle synergies and demonstrating similarities in synergy compositions across different locomotor modes in chimpanzees and Japanese macaques.
View Article and Find Full Text PDFMol Med
December 2024
Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species.
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