Joel Cohen offers a historical and prospective analysis of the relationship between mathematics and biology
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| http://dx.doi.org/10.1371/journal.pbio.0020439 | DOI Listing |
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Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings.
Malar J
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MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Background: The availability of many tools for malaria control leads to complex decisions regarding the most cost-effective intervention package based on local epidemiology. Mosquito characteristics influence the impact of vector control, but entomological surveillance is often limited due to a lack of resources in national malaria programmes.
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Department of Biology, College of Sciences and Arts Khulais, University of Jeddah, 21959, Jeddah, Saudi Arabia.
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View Article and Find Full Text PDFCell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction.
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Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico-Chimie Curie, 75005, Paris, France.
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Department of Mechanical and Metallurgical Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, iHEALTH, Chile. Electronic address:
The identification of the Purkinje conduction system in the heart is a challenging task, yet essential for a correct definition of cardiac digital twins for precision cardiology. Here, we propose a probabilistic approach for identifying the Purkinje network from non-invasive clinical data such as the standard electrocardiogram (ECG). We use cardiac imaging to build an anatomically accurate model of the ventricles; we algorithmically generate a rule-based Purkinje network tailored to the anatomy; we simulate physiological electrocardiograms with a fast model; we identify the geometrical and electrical parameters of the Purkinje-ECG model with Bayesian optimization and approximate Bayesian computation.
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Proc Natl Acad Sci U S A
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Courant Institute for Mathematical Sciences and Department of Biology, New York University, New York, NY 10012.
Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate connections are formed and rapidly corrected throughout the mitotic stages, but a small number of merotelic connections, in which a chromatid is connected to both spindle poles, remain lagging at the spindle's equator in anaphase. Most of the lagging chromatids are eventually moved to one or the other pole, likely by a combination of microtubules' turnover and the brute force of pulling by the microtubules' majority from the one pole against the microtubules' minority from the other pole.
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