Twenty-one subjects underwent event-related fMRI while carrying out a simple visuomotor task in which they responded to stimuli flashed either onto the right visual field, onto the left visual field, or onto both visual fields at once. The aim of this study was to clarify areas of brain activity associated with crossed-uncrossed differences (CUD) and to investigate differences of the brain activity between CUD and redundancy gain. An intriguing brain activation related to CUD was found in the genu of the corpus callosum (CC). The sites of activation related to redundancy gain were the extrastriate cortex and the cingulate cortex. Our results suggested that CUD depended on the interhemispheric transfer via the CC, and that CUD and redundancy gain involved different brain mechanisms.
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J Mol Neurosci
January 2025
Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Alzheimer's disease (AD) is a neurodegenerative disease with no effective treatment, often preceded by mild cognitive impairment (MCI). Multimodal imaging genetics integrates imaging and genetic data to gain a deeper understanding of disease progression and individual variations. This study focuses on exploring the mechanisms that drive the transition from normal cognition to MCI and ultimately to AD.
View Article and Find Full Text PDFCells
December 2024
Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy.
() genes play an important role in the proper formation of retinal cells in vertebrates, in particular horizontal, retinal ganglion and amacrine cells. However, it is not fully known how the unique and combined action of multiple gene copies leads to the induction and differentiation of specific retinal cell types. To gain new insights on how genes influence retina formation, we have examined the developmental role of , and genes during eye formation in the non-mammalian vertebrate zebrafish .
View Article and Find Full Text PDFComput Biol Chem
January 2025
School of Mechanical, Electrical and Information Engineering, Shandong University at Weihai, 264209, China. Electronic address:
Long non-coding RNAs (lncRNAs) are strongly associated with cellular physiological mechanisms and implicated in the numerous diseases. By exploring the subcellular localizations of lncRNAs, we can not only gain crucial insights into the molecular mechanisms of lncRNA-related biological processes but also make valuable contributions towards the diagnosis, prevention, and treatment of various human diseases. However, conventional experimental techniques tend to be laborious and time-intensive.
View Article and Find Full Text PDFComput Biol Med
December 2024
Faculty of Engineering, Computing and the Environment, Kingston University, Penrhyn Road Campus, Kingston Upon Thames, London, KT1 2EE, UK.
In recent years, gene expression data analysis has gained growing significance in the fields of machine learning and computational biology. Typically, microarray gene datasets exhibit a scenario where the number of features exceeds the number of samples, resulting in an ill-posed and underdetermined equation system. The presence of redundant features in high-dimensional data leads to suboptimal performance and increased computational time for learning algorithms.
View Article and Find Full Text PDFElife
December 2024
School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.
Marcks and Marcksl1 are abundant proteins that shuttle between the cytoplasm and membrane to modulate multiple cellular processes, including cytoskeletal dynamics, proliferation, and secretion. Here, we performed loss- and gain-of-function experiments in to reveal the novel roles of these proteins in spinal cord development and regeneration. We show that Marcks and Marcksl1 have partly redundant functions and are required for normal neurite formation and proliferation of neuro-glial progenitors during embryonic spinal cord development and for its regeneration during tadpole stages.
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