The last few years has seen a revolution in combinatorial chemistry, an approach that has been developed for the synthesis of chemical libraries for application within the pharmaceutical industry. Many chemical methods have been investigated, which can be utilized in all manner of strategies for library synthesis, including reactions of diazocarbonyls. This review discusses the application of diazocarbonyl functionalized molecules for the preparation of chemical libraries.
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IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.
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Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California91125, United States.
Sequence-function data provides valuable information about the protein functional landscape but is rarely obtained during directed evolution campaigns. Here, we present Long-read every variant Sequencing (LevSeq), a pipeline that combines a dual barcoding strategy with nanopore sequencing to rapidly generate sequence-function data for entire protein-coding genes. LevSeq integrates into existing protein engineering workflows and comes with open-source software for data analysis and visualization.
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Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
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