AI Article Synopsis
- The study aimed to evaluate how autologous blood transfusion affects immune activation in patients with malignant stomach tumors by measuring Serum Neopterin and IL-2 levels.
- Sixty patients were split into two groups: one receiving autologous transfusions and the other receiving allogeneic transfusions, with measurements taken before anesthesia, after surgery, and five days post-op.
- Results showed that autologous transfusion led to lower Serum Neopterin levels post-operation, indicating less immune suppression compared to allogeneic transfusion, which also showed decreased levels of both Neopterin and IL-2 but to a greater extent.
Article Abstract
Objective: To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured.
Methods: Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared.
Results: In group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation.
Conclusion: Autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390759 | PMC |
| http://dx.doi.org/10.1631/jzus.2005.B0049 | DOI Listing |
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