AI Article Synopsis
- - A patient who received a hematopoietic stem cell transplantation exhibited severe diarrhea and fever, leading to a positive rapid test for adenovirus (AdV) in stool samples.
- - Although conventional and real-time PCR did not detect the AdV genome, specific PCR confirmed the presence of AdV serotype 7 through targeted gene analysis.
- - The treatment with cidofovir (CDV) at a dosage of 1 mg/kg intravenously three times a week proved effective in addressing the adenovirus infection.
Article Abstract
A hematopoietic stem cell transplantation (SCT) recipient developed severe diarrhea and fever. A rapid test for the presence of adenovirus (AdV)-specific antigen in the patient's stools was positive; however, AdV genome was not detected by conventional or real-time polymerase chain reaction (PCR). AdV was confirmed by specific PCR for AdV serotype 7 and by an AdV hexon/fiber gene DNA sequence homology search of the PCR product. We suspect that conventional/real-time PCR failed to detect AdV due to nine silent single base substitutions in the extracted AdV genome. Treatment with 1 mg/kg cidofovir (CDV) intravenously three times a week was effective.
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| http://dx.doi.org/10.1002/pbc.20275 | DOI Listing |
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