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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids Barriers CNS
January 2025
Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven - University of Leuven, O&N II Herestraat 49 box 820, 3000, Leuven, Belgium.
Background: Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT) by targeting nutrient receptors to shuttle protein therapeutics over the blood-brain barrier (BBB) along with their endogenous cargos. While higher brain exposure is achieved with RMT, the timeframe is short due to rather fast brain clearance.
View Article and Find Full Text PDFHighly sensitive, responsive, and selective iodine gas sensor fabricated using AgI-functionalized graphene.
Nat Commun
January 2025
School of Emergent Soft Matter, South China University of Technology, Guangzhou, China.
Radioactive molecular iodine (I) is a critical volatile pollutant generated in nuclear energy applications, necessitating sensors that rapidly and selectively detect low concentrations of I vapor to protect human health and the environment. In this study, we design and prepare a three-component sensing material comprising reduced graphene oxide (rGO) as the substrate, silver iodide (AgI) particles as active sites, and polystyrene sulfonate as an additive. The AgI particles enable reversible adsorption and conversion of I molecules into polyiodides, inducing substantial charge density variation in rGO.
View Article and Find Full Text PDFImpact of Gd, Pr, Yb, and Nd doping on the magnetic properties of Mg-ferrite nanoparticles.
J Mater Sci Mater Med
January 2025
Cyclotron Facility, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt.
This study aimed to synthesize MgFeLnO (where, Ln = Yb, Pr, Gd, and Nd) ferrite nanoparticles via the sol-gel process and investigate their structural, morphological, and magnetic properties for potential hyperthermia applications. X-ray diffraction analysis (XRD) confirmed the cubic spinel structure for all samples. Transmission electron microscopy (TEM) images revealed nanometer-scale dimensions and nearly spherical morphology.
View Article and Find Full Text PDFActivation of megakaryocytic leukemia 1 in endothelial cells contributes to diabetic retinopathy in mice.
Life Sci
January 2025
Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China; Department of Ophthalmology, Friendship Hospital of Ili Kazakh Autonomous Prefecture, Ili, China. Electronic address:
Aims: Diabetic retinopathy (DR) represents one of the most devastating sequences in patients with diabetes. Endothelial dysfunction is a key pathological feature and contributing factor to DR. In the present study we investigated the role of megakaryocytic leukemia 1 (MKL1) in DR pathogenesis.
View Article and Find Full Text PDFPhotochemical bomb: Precision nuclear targeting to activate cGAS-STING pathway for enhanced bladder cancer immunotherapy.
Biomaterials
January 2025
Department of Urology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, China; Department of Urology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:
Activating the cGAS-STING pathway presents a promising strategy to enhance the innate immunity and combat the immunosuppressive tumor microenvironment. One key mechanism for triggering this pathway involves the release of damaged DNA fragments caused by nuclear DNA damage. However, conventional cGAS-STING agonists often suffer from limited nucleus-targeting efficiency and potential biotoxicity.
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