AI Article Synopsis
- The study describes a new IVF approach that uses both mature oocytes from dominant follicles and immature oocytes from smaller follicles.
- Three women with normal and polycystic ovaries participated, resulting in three pregnancies—two live births and one ongoing.
- The findings suggest that combining natural-cycle IVF with in vitro maturation (IVM) could be effective for treating different types of infertility.
Article Abstract
Objective: To describe pregnancies and live births that resulted from IVF of mature oocytes retrieved from dominant follicles in a natural cycle combined with in vitro maturation (IVM) of immature oocytes retrieved from small follicles.
Design: Case reports.
Setting: McGill Reproductive Center, Royal Victoria Hospital, McGill University.
Patient(s): Three women with normal ovaries or polycystic ovaries who underwent infertility treatment.
Intervention(s): Administration of s.c. hCG (10,000 IU) 36 hours before oocyte retrieval in a natural cycle. After aspiration of all follicles, mature oocytes were inseminated immediately; immature oocytes were matured in vitro, inseminated by intracytoplasmic sperm injection (ICSI), and then the embryos transferred.
Main Outcome Measure(s): Pregnancy and live birth.
Result(s): Three pregnancies (two live births and one ongoing at time of writing) were achieved after the combination of natural-cycle IVF with IVM after transfer of the resulting embryos.
Conclusion(s): Natural-cycle IVF combined with IVM might be a new approach to IVF treatment for women with various causes of infertility.
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| http://dx.doi.org/10.1016/j.fertnstert.2004.04.060 | DOI Listing |
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