Azoospermia in testicular sarcoidosis is an indication for corticosteroid therapy.

Objective: To report improvement of azoospermia and hypogonadism after high-dose corticosteroid therapy in a patient with testicular sarcoidosis.

Design: Case report.

Setting: University hospital.

Patient(s): A 27-year-old man with testicular sarcoidosis and azoospermia.

Intervention(s): High-dose corticosteroid therapy was commenced in an attempt to improve sperm count and restore gonadal function.

Main Outcome Measure(s): Analysis of sperm count, T, and gonadotropin response to steroid therapy.

Result(s): FSH and LH concentrations decreased and T levels increased in parallel with control of disease activity with steroid therapy. Repeat semen analysis demonstrated a significant increase in sperm count, allowing sperm banking to take place.

Conclusion(s): High-dose corticosteroid therapy may be indicated in testicular sarcoidosis, not only for control of systemic disease activity but also for recovery of gonadal function and spermatogenesis.