This work studied the interactions between cholinergic and adenosine systems in the denervated striatum. For that purpose, we evaluated the effects of an intrastriatal administration of the muscarincic receptor agonist, oxotremorine-M on turning behavior induced by systemic caffeine in unilaterally 6-hydroxydopamine-lesioned rats. Low doses of oxotremorine-M (0.1 ng/microl) enhanced, whereas high doses (100 ng/microl) attenuated contralateral turning induced by caffeine. These results support a functional link between muscarinic and adenosinergic systems in the denervated striatum and suggest opposite actions of muscarinic M2 and M1 receptors on caffeine-induced turning behavior.
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http://dx.doi.org/10.1016/j.ejphar.2004.10.009 | DOI Listing |
Chaos
January 2025
Departamento de Física, Universidad Nacional de Colombia, Bogotá, Colombia.
We consider a discrete-time Markovian random walk with resets on a connected undirected network. The resets, in which the walker is relocated to randomly chosen nodes, are governed by an independent discrete-time renewal process. Some nodes of the network are target nodes, and we focus on the statistics of first hitting of these nodes.
View Article and Find Full Text PDFBackground: Mild cognitive impairment (MCI) is a clinical cognitive deficit that is not severe enough to meet the threshold for Alzheimer's Disease (AD); however, MCI patients have an increased risk of developing AD. Therefore, a diagnosis of MCI may represent a critical turning point in the trajectory of developing AD. Establishing neurological signatures of MCI using network control theory (NCT) may allow more informed diagnosis, and an understanding of its underlying mechanisms could pave the way for novel treatments.
View Article and Find Full Text PDFBackground: In Japan, the increase in the number of accidents involving elderly drivers has become a very serious problem. The government has implemented a cognitive function test at the time of driver's license renewal and has taken measures to disallow driving by elderly drivers with Alzheimer's disease, but drivers with MCI and other types of dementia continue to drive. One of the measures recommended to contribute to the safe driving of elderly drivers is to encourage them to talk to their passengers.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Yonsei New-normal Lfiestyle Resarch Center, Yonsei University, Wonju, Gangwon-do, Korea, Republic of (South).
Background: Retirement for elderly people marks a critical turning point in life, acting as a significant personal and social event associated with both positive and negative health impacts. Studies on elderly populations from the successful aging perspective suggest that individual efforts and external support are necessary for successful aging. The WHO emphasizes the importance of a healthy lifestyle in achieving health and well-being in human life and indicates the need for professional programs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Toronto, Toronto, ON, Canada.
Background: Commercially available exercise video games ('exergames') can be used by people with dementia with the right (human) prompting and support. However, more information is needed about what makes these systems and games technologically accessible for this population, considering their cognitive difficulties. This study explores what works and doesn't work for people with dementia when introducing new exergame systems and games to broaden opportunities for physical activity.
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