Background: Myocardial infarction, a major complication of non-cardiac surgery, impacts on perioperative morbidity and mortality.
Methods: We retrospectively reviewed the intensive care unit records and anesthesia charts of non-cardiac surgical patients needing cardiac intensive care for myocardial infarction from April 1998 to December 2000 at the University of Tokyo Hospital and analyzed data obtained from these records.
Results: Four cases were detected. Three were vascular patients. The myocardial infarction occurred in two patients preoperatively, in one intraoperatively, and in another postoperatively. Hypovolemia was considered as an important contributing factor. All the patients developed shock abruptly and cardiac arrest followed in three. Three needed intra-aortic balloon counterpulsation, and one of these needed percutaneous cardiopulmonary support. Emergent percutaneous coronary intervention was performed in all cases and resuscitation was successful temporarily in all patients. However, the clinical outcome was poor; three died in our hospital and one transferred to another hospital became severely disabled.
Conclusions: Surgical patients can be asymptomatic although they have significant coronary artery disease. Most of the events occurred abruptly without preexisting myocardial ischemia, suggesting the pathophysiology causing acute coronary syndrome. Thorough cardiac examination, including coronary angiography is recommended preoperatively in patients with strong coronary risks, especially in vascular patients.
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Front Biosci (Landmark Ed)
January 2025
Department of Cardiology, Affiliated Hospital of Jiangnan University, 214122 Wuxi, Jiangsu, China.
Background: Myocardial ischemia-reperfusion (I/R) injury refers to cell damage that occurs as a consequence of the restoration of blood circulation following reperfusion therapy for cardiovascular diseases, and it is a primary cause of myocardial infarction. The search for nove therapeutic targets in the context of I/R injury is currently a highly active area of research. p70 ribosomal S6 kinase (S6K1) plays an important role in I/R induced necrosis, although the specific mechanisms remain unclear.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, 401336 Chongqing, China.
Background: Myocardial ischemia-reperfusion (I/R) injury and coronary microcirculation dysfunction (CMD) are observed in patients with myocardial infarction after vascular recanalization. The antianginal drug trimetazidine has been demonstrated to exert a protective effect in myocardial ischemia-reperfusion injury.
Objectives: This study aimed to investigate the role of trimetazidine in endothelial cell dysfunction caused by myocardial I/R injury and thus improve coronary microcirculation.
J Investig Med High Impact Case Rep
January 2025
LSU Health Shreveport, LA, USA.
An 18-year-old teenager with significant atherosclerotic cardiovascular disease (ASCVD) risk factors developed acute chest pain. His electrocardiogram showed inferior ST-segment elevations. Emergent coronary angiogram revealed complete thrombotic occlusion of the right coronary artery.
View Article and Find Full Text PDFJ Clin Med
January 2025
Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York, NY 10467, USA.
Primary percutaneous coronary intervention (PCI) has revolutionized the management of ST-elevation myocardial infarction (STEMI), markedly improving patient outcomes. Despite technological advancements, pharmacological innovations, and refined interventional techniques, STEMI prognosis remains burdened by a persistent incidence of cardiac death and heart failure (HF), with mortality rates plateauing over the last decade. This review examines current practices in primary PCI, focusing on critical factors influencing patient outcomes.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Cardiology, Angiology and Intensive Care, Philipps University Marburg, 35043 Marburg, Germany.
Emerging evidence suggests the role of mechanical circulatory support (MCS) devices in the therapy of refractory cardiogenic shock (CS). However, largerandomized trials addressing the role of Impella in the therapy of infarct-associated CS are sparse. As such, evidence coming from comprehensive retrospective studies or meta-analyses is of major importance in order to clarify the role of the Impella device in this setting.
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