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Introduction: Hypertension and diabetes are leading causes of adult hospital admissions and mortality across health facilities in Ghana. Timely screening and diagnosis at primary health facilities are crucial to initiate treatment and avert complications. This study explored service availability and readiness of health systems for managing hypertension and diabetes in selected district hospitals in Ghana.
View Article and Find Full Text PDFInsulin Resistance in Hypercalciuric Calcium Kidney Stone Patients.
Kidney Med
December 2024
Department of Medicine, University of Chicago, Chicago IL.
Rational & Objective: Diabetes and uric acid kidney stones are strongly associated. Patients with calcium kidney stones also have higher risk of developing diabetes compared with nonkidney stone patients yet this has not been further investigated. We aimed to characterize insulin resistance in calcium kidney stone patients.
View Article and Find Full Text PDFUse of renin-angiotensin system blockers and posttraumatic stress disorder risk in the UK Biobank: a retrospective cohort study.
BMC Med
October 2024
Department of Preventive Medicine, Yonsei University College of Medicine, Yonsei-Ro 50-1, Seodaemun-Gu, Seoul, 03722, South Korea.
Background: Previous research has shown that the use of renin-angiotensin system (RAS) blockers is linked to a lower prevalence of posttraumatic stress disorder (PTSD), but longitudinal studies are scarce. We aimed to estimate the association between the use of RAS blockers and the risk of PTSD among individuals taking antihypertensive medications.
Methods: This longitudinal study included participants aged 40-69 from the UK Biobank.
Pharmacotherapy for patients with calcium oxalate stones and abnormal urine chemistry: A systematic review and meta-analysis for the Japanese Clinical Practice Guidelines for the Management of Urinary Stones, Third Edition.
Int J Urol
January 2025
Department of Urology, Wakayama Medical University, Wakayama, Japan.
We performed a systematic review and meta-analysis to evaluate the benefits and harms of pharmacotherapies for patients with calcium oxalate stones and abnormal urine chemistry. This article is a modified and detailed version of the commentary on Clinical Question 10 described in the Japanese Clinical Practice Guidelines for the Management of Urinary Stones, Third Edition. PubMed and Ichushi Web were searched through August 2020 for articles on pharmacotherapies for calcium oxalate stones (thiazides, citrate preparations, uric acid production inhibitors, and magnesium preparations).
View Article and Find Full Text PDFMulti- and poly-pharmacology of carbonic anhydrase inhibitors.
Pharmacol Rev
September 2024
Neurofarba Department, University of Firenze, Italy
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2.1.
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