AI Article Synopsis
- Phase angle, measured through bioelectrical impedance analysis, indicates tissue electrical changes and serves as a predictor of survival in chronic conditions like HIV and cancer.
- In a study of 52 stage IV colorectal cancer patients, those with a phase angle ≤5.57 had a median survival of 8.6 months, while those with a phase angle >5.57 had 40.4 months, highlighting a significant survival difference.
- The findings suggest that phase angle is a valuable prognostic factor for advanced colorectal cancer, and further research with larger groups is necessary to explore its role in other cancer types.
Article Abstract
Background: Phase angle, determined by bioelectrical impedance analysis (BIA), detects changes in tissue electrical properties and has been found to be a prognostic indicator in several chronic conditions-such as HIV, liver cirrhosis, chronic obstructive pulmonary disease, and lung cancer-and in patients receiving dialysis.
Objective: This study was conducted to investigate the prognostic role of phase angle in advanced colorectal cancer.
Design: We evaluated a case series of 52 patients with histologically confirmed stage IV colorectal cancer. BIA was conducted on all patients and phase angle was calculated. The Kaplan-Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle independent of other clinical and nutritional variables.
Results: Patients with a phase angle < or =5.57 had a median survival of 8.6 mo (95% CI: 4.8, 12.4; n=26), whereas those with a phase angle >5.57 had a median survival of 40.4 mo (95% CI: 21.9, 58.8; n=26; P=0.0001).
Conclusion: Phase angle is a prognostic indicator in patients with advanced colorectal cancer. Similar studies of other cancer types with larger sample sizes are needed to further validate the prognostic significance of phase angle in cancer treatment settings.
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| http://dx.doi.org/10.1093/ajcn/80.6.1634 | DOI Listing |
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