Objective: To evaluate the efficacy of cognitive behaviour therapy for adolescents aged 10-17 years with chronic fatigue syndrome.
Design: Randomised controlled trial.
Setting: Department of child psychology.
Participants: 71 consecutively referred patients with chronic fatigue syndrome; 36 were randomly assigned to immediate cognitive behaviour therapy and 35 to the waiting list for therapy.
Intervention: 10 sessions of therapy over five months. Treatment protocols depended on the type of activity pattern (relatively active or passive). All participants were assessed again after five months.
Main Outcome Measures: Fatigue severity (checklist individual strength), functional impairment (SF-36 physical functioning), and school attendance.
Results: 62 patients had complete data at five months (29 in the immediate therapy group and 33 on the waiting list). Patients in the therapy group reported significantly greater decrease in fatigue severity (difference in decrease on checklist individual strength was 14.5, 95% confidence interval 7.4 to 21.6) and functional impairment (difference in increase on SF-36 physical functioning was 17.3, 6.2 to 28.4) and their attendance at school increased significantly (difference in increase in percentage school attendance was 18.2, 0.8 to 35.5). They also reported a significant reduction in several accompanying symptoms. Self reported improvement was largest in the therapy group.
Conclusion: Cognitive behaviour therapy is an effective treatment for chronic fatigue syndrome in adolescents.
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http://dx.doi.org/10.1136/bmj.38301.587106.63 | DOI Listing |
Am J Geriatr Psychiatry
December 2024
Department of Gerontology, Faculty of Social Welfare & Health Sciences, University of Haifa, 199 Aba Khoushy Ave, Haifa, 3498838, Israel. Electronic address:
Objective: Unidentified sex differences in old-age cognition may emerge in psychometric networks, which look beyond mean scores into the unique cognitive structure of males and females. Accordingly, this study aims to examine cognition in well-functioning older males and females with psychometric network analysis.
Methods: The current cohort (N = 2,802) of community-dwelling adults (≥65 years) was derived from the Advanced Cognitive Training for Independent and Vital Elderly study.
Neurobiol Aging
December 2024
Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA.
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects.
View Article and Find Full Text PDFBrain Cogn
January 2025
Department of Psychology, Hunan Normal University, Changsha 410081, China; Cognition and Human Behavior Key Laboratory of Hunan Province, Changsha 410081, China; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha 410081, China. Electronic address:
With the increasing urgency of environmental degradation, it is crucial to investigate whether and why individuals from different socioeconomic statuses (SES) engage in environmental donations within social contexts to develop targeted strategies that promote environmental sustainability. However, the psychological mechanisms and neural activities underlying environmental donations across SES in social contexts remain unclear. The current study randomly assigned participants to high (low) SES groups and asked them to complete the environmental donation task in the (non) observable contexts while the electroencephalogram was recorded.
View Article and Find Full Text PDFNeuropeptides
January 2025
Affiliated Rehabilitation Hospital, Jiang Xi Medical College, Nanchang University, Nanchang 330003, Jiangxi, China; Rehabilitation Medicine Clinical Research Center of Jiangxi Province, 330003, Jiangxi, China; Key Laboratory of Jiangxi Provincial Health Commission for DOC Rehabilitation, 330003, Jiangxi, China. Electronic address:
Traumatic brain injury (TBI) is a life-threatening condition with high incidence and mortality rates. The current pharmacological interventions for TBI exhibit limited efficacy, underscoring the necessity to explore novel and effective therapeutic approaches to ameliorate its impact. Previous studies have indicated that transcranial pulsed current stimulation (tPCS) can improve neurofunctional deficits in patients by modulating brain neuroplasticity.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.
The present study investigated the neuromodulatory substrates of salience processing and its impact on memory encoding and behaviour, with a specific focus on two distinct types of salience: reward and contextual unexpectedness. 46 Participants performed a novel task paradigm modulating these two aspects independently and allowing for investigating their distinct and interactive effects on memory encoding while undergoing high-resolution fMRI. By using advanced image processing techniques tailored to examine midbrain and brainstem nuclei with high precision, our study additionally aimed to elucidate differential activation patterns in subcortical nuclei in response to reward-associated and contextually unexpected stimuli, including distinct pathways involving in particular dopaminergic modulation.
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