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Multi-omics analysis of druggable genes to facilitate Alzheimer's disease therapy: A multi-cohort machine learning study.
J Prev Alzheimers Dis
March 2025
Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: The swift rise in the prevalence of Alzheimer's disease (AD) alongside its significant societal and economic impact has created a pressing demand for effective interventions and treatments. However, there are no available treatments that can modify the progression of the disease.
Methods: Eight AD brain tissues datasets and three blood datasets were obtained.
Unveiling the molecular activity of HIV towards the CD4: A study based on subtype C via docking and dynamics approach.
J Genet Eng Biotechnol
March 2025
Department of Bioinformatics, University of North Bengal, District-Darjeeling, West Bengal 734013, India. Electronic address:
Background: Acquired Immunodeficiency Syndrome (AIDS) is a critical global health issue caused by the human immunodeficiency virus (HIV). It has different strains and subtypes; among these, Subtype C accounts for higher infection rates than others. Despite its high prevalence, the molecular interactions with host receptors, specifically CD4, have not yet been explored.
View Article and Find Full Text PDFThe protective role of school connectedness in the relationship between child maltreatment and internalizing symptoms for White, Black, Latino/Hispanic, and multiracial youth.
Child Abuse Negl
March 2025
School of Social Work, University of Michigan, Ann Arbor, MI, USA.
Background: Child maltreatment is a public health concern associated with increased youth internalizing symptoms. School connectedness has been shown to play a protective role in the relationship between child maltreatment and externalizing symptoms; yet, its protective role on internalizing symptoms for youth in different racial/ethnic subgroups remains underexplored.
Objective: This study aimed to examine whether school connectedness buffers the effect of child maltreatment on internalizing symptoms for White, Black, Latino/Hispanic, and multiracial youth.
A novel reassorted swine H3N2 influenza virus demonstrates an undetected human-to-swine spillover in Latin America and highlights zoonotic risks.
Virology
March 2025
Grupo de Investigación en Microbiología y Epidemiología, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogotá, 111321, Colombia. Electronic address:
Influenza A virus (FLUAV) affects a wide range of hosts, including humans and animals, posing a threat to public health. In swine, H3N2 subtype is associated with human-to-swine spillovers of seasonal viruses. In Latin America, the molecular and antigenic characteristics of swine FLUAV H3N2, as well as its phylogenetic origin, are poorly understood.
View Article and Find Full Text PDFOptimizing Biomarker Models for Biologically Heterogeneous Cancers: A Nested Model Approach for Lung Cancer.
Cancer Epidemiol Biomarkers Prev
March 2025
Vanderbilt University Medical Center, Nashville, Tennessee.
Background: The heterogeneous biology of cancer subtypes, especially in lung cancer, poses significant challenges for biomarker development. Standard model building techniques often fall short in accurately incorporating various histologic subtypes because of their diverse biological characteristics. This study explores a nested biomarker model to address this issue, aiming to improve lung cancer early detection.
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