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Identification and Management of Medical Comorbidities in Patients With HR+/HER2- Metastatic Breast Cancer Treated With CDK4/6 Inhibitors: Literature Review and Recommendations From Experts in Spain Opinion.
Clin Breast Cancer
December 2024
Navarra University Hospital, Pamplona, Navarra, Spain. Electronic address:
Approximately one-third of patients with breast cancer have comorbidities at the time of their diagnosis. Recommendations for managing metastatic breast cancer are usually based on the results of clinical trials, which often limit patients with comorbidities. However, comorbidities greatly influence the quality of life, patient survival rate and treatment choice, particularly in older patients.
View Article and Find Full Text PDFObjectives: This study aimed to develop a prediction model for the detection of early sepsis-associated acute kidney injury (SA-AKI), which is defined as AKI diagnosed within 48 hours of a sepsis diagnosis.
Design: A retrospective study design was employed. It is not linked to a clinical trial.
ALTERNATIVE AUTOLOGOUS VEIN GRAFTS VERSUS SINGLE SEGMENT GREAT SAPHENOUS VEIN IN LOWER EXTREMITY BYPASS SURGERY - SINGLE-CENTER STUDY.
Ann Vasc Surg
January 2025
1(st) Department of Pathology, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic.
Objectives: Studies comparing alternative autologous vein grafts (AAVG) to single-segment great saphenous vein (ssGSV) grafts report mixed results. The status of AAVG as first choice when ssGSV is unavailable is not unequivocal, based on current evidence. Our study compares results between AAVG and ssGSV in lower extremity bypass surgery.
View Article and Find Full Text PDFNon-atherosclerotic coronary causes of myocardial infarction in women.
Prog Cardiovasc Dis
January 2025
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States. Electronic address:
Ischemic heart disease is the most common cardiovascular cause of death in women worldwide. Obstructive coronary atherosclerosis is the primary cause of myocardial infarction (MI), however, non-atherosclerotic mechanisms of MI, such as spontaneous coronary artery dissection, vasospasm, microvascular dysfunction, embolization, inflammation, coronary anomalies, infectious and infiltrative causes are increasingly being recognized. Emerging data suggest that women are two to five times more likely to have an MI in the absence of coronary atherosclerosis compared to men, but they continue to remain underdiagnosed and undertreated, partly due to underdiagnosis and limited understanding of these mechanisms.
View Article and Find Full Text PDFPatterns of reflux in patients with CEAP C2 disease compared to patients with C6 venous ulceration.
Phlebology
January 2025
Center for Vascular Medicine, Glen Burnie, MD, USA.
Objective: CEAP categorizes patients based on disease progression and severity. Whether disease severity is associated with specific patterns of reflux is currently unknown. We hypothesize that patterns of reflux in patients with C2 and C5/6 disease will differ.
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